The Effect of Different Drugs on plasma ACTH and COR of rat with posttraumatic stress disorder
LIU Min1,YUAN Hong2,CHEN Jinhong2,ZHENG Chunxiu2,ZHANG Zhenwen2,LIANG Liwu2,and ZHENG Jingchen2
1.Department of Traditional Chinese Medicine, Xijing Hospital, Fourth Military Medical University of PLA, Xi’an 710032, China;
2. General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China
Abstract：Objective To explore the effects of ganmaidazao Decoction(GMDZ Decoction), zhizichi Decoction(ZZC Decoction)and Gastrodine capsule on ACTH and COR in plasma of PTSD rats. Methods Forty male rats were divided into five groups: control group, model group, group of GMDZ Decoction, group of ZZC Decoction, group of Gastrodine. Using SPS animal model ,three drugs were fed for 14 days after SPS of rats. The plasm levels of ACTH, COR were detected by radioimmunoassay. Results The result showed that the plasm levels of ACTH, COR were significantly increase in SPS model of rats in comparison with control group (P<0. 01). GMDZ Decoction, ZZC Decoction and Gastrodine could descend the contents of ACTH and COR, and there was no significant difference between three drug groups(P>0.05). Conclusions The drugs of GMDZ Decoction, ZZC Decoction and Gastrodine capsule can modulate the endocrine function disorder of PTSD rat.
刘 敏,袁 红,陈金宏,郑春秀,张振文,梁立武,郑静晨. 不同药物对创伤后应激障碍大鼠血浆促肾上腺皮质激素和皮质醇的影响[J]. 武警医学, 2013, 24(5): 422-424.
LIU Min,YUAN Hong,CHEN Jinhong,ZHENG Chunxiu,ZHANG Zhenwen,LIANG Liwu,and ZHENG Jingchen. The Effect of Different Drugs on plasma ACTH and COR of rat with posttraumatic stress disorder. Med. J. Chin. Peop. Armed Poli. Forc., 2013, 24(5): 422-424.
American Psychiatric Association Diagnostic and statistic mental disorders,4th edn (DSM-IV).American Psychiatric Association, Washington, DC.1994.
[1]
American Psychiatric Association Diagnostic and statistic mental disorders,4th edn (DSM-IV).American Psychiatric Association, Washington, DC.1994.
[2]
First M, Spitzer R, Williams J, et al. Structured clinical interview for DSM-IV axis I disorders (SCID-I). In: Handbook of psychiatric measures. Washington (DC): American Psychiatric Association,2000:49-53.
First M, Spitzer R, Williams J, et al. Structured clinical interview for DSM-IV axis I disorders (SCID-I). In: Handbook of psychiatric measures. Washington (DC): American Psychiatric Association,2000:49-53.
2013, Vol. 24 
