T lymphocytes and cytokine levels change in patients with chronic obstructive pulmonary disease
HU Yunqu1,REN Haibo2,SONG Xuan3,LI Yuzhu4,and CUI Zhiru5
1.Department of Respiratory Medicine,
2.Anesthesiology,
3. Laboratory. Urumqi 830091,China;
4. Department of respiration, General Hospital of PLA. Beijing 100853,China;
5. Department of Nursery,Inner Mongolian Autonomous Region Corps Hospital,Chinese People’s Armed Police Forces,Hohhot 010040,China
Abstract：Objective To study changes in T lymphocyte subsets of features and cytokine interleukin hormone (IL)-6,IL-8, tumor necrosis factor (TNF-α) in patients with chronic obstructive pulmonary disease (COPD) and the clinical significance. Methods Peripheral blood T cell subsets and serum IL-6,IL-8,TNF-α level were detected in admitted 80 patients with acute exacerbation of COPD and a control group of 30 healthy subjects.Analysis and comparison of the differences,and correlation with forced expiratory volume in one second (FEVI) were made.Results In COPD group, total T cells (CD3+), Th cells, Th / Ts ratio, natural killer (NK) cells were lower than those in control group, the difference was statistically significant (P<0.05). COPD group at time of admission had significantly higher serum IL-8, IL-6 and TNF-α levels , the difference was statistically significant (P<0.05); there were negative correlation between IL-6, IL-8, TNF-α and FEV1 (r=-0.74,-0.69,-0.76, P<0.05, respectively). Conclusion T lymphocyte subsets and cytokine are jointly involved in the inflammatory reaction in COPD,these changes play an important role in the development of COPD process,and can be used as an important indicator for monitoring of the disease.
GOLD Executive Committee.Global strategy for the diagnosis,management,and prevention of chronic obstructive pulmonary disease (Revised 2011)[EB/OL].[2012-01-16].
[1]
GOLD Executive Committee.Global strategy for the diagnosis,management,and prevention of chronic obstructive pulmonary disease (Revised 2011)[EB/OL].[2012-01-16].
[2]
Barcel6 B,Pons J,Ferrer J M,et al.Phenotypic characterissfion of T-lymphoeytes in COPD:abnormal CD3+CD25+regulatory T-lymphocyte response to tobacco smoking[J].Eur Respir J,2008,31(3):555-562.
[2]
Barcel6 B,Pons J,Ferrer J M,et al.Phenotypic characterissfion of T-lymphoeytes in COPD:abnormal CD3+CD25+regulatory T-lymphocyte response to tobacco smoking[J].Eur Respir J,2008,31(3):555-562.
2013, Vol. 24 
