Clinical characteristics and prognostic analysis of pseudomyxoma peritonei
WEI Zhenjun1,LI Hongyi1,LIANG Hao2,and LUO Jizheng1.
1.Department of Geriatric Gastroenterology,General Hospital of Beijing Millitary Command,Beijing 100700, China; 2.Department of Gastroenterology,General Hospital of PLA, Beijing 100853, China
Abstract：Objective To investigate the clinical features and prognostic factors of pseudomyxoma peritonei(PMP). Methods The clinical characteristics and follow-up data of 23 patients with PMP admitted to the General Hospital of PLA in the past fourteen years were retrospectively analyzed.Survival analysis was evaluated through Kaplan-Meier and Log-rank tests. Results The mean age was 56.6±12.8 (range 36～75)(57%male, 43%female). Abdominal distension, mass and pain were major symptoms. Ascites and mass were often found in the examination of abdominal imaging such as CT and ultrosonography. Of 23 patients,17 underwent debulking surgery and 3 had complete cytoreductive surgery. Intraperitoneal chemotherapies were followed after surgery in 9 patients. Survival analysis(Kaplan-Meier method) showed that the median survival time was 120.0 months and 3-,5-,10-years survival rates were 79.7%,54.7%,27.3%,respectively. Survival time of patients was closely correlated with primary appendiceal neoplasm. Conclusions Preoperative diagnosis of PMP is difficult, imagings including CT and ultrasonography are beneficial to the definite diagnosis. Pathological type of appendiceal mucinous neoplasm affects the survival of patients with PMP.Surgery combined with intraperitoneal chemotherapy is the standard treatment and can improve short-term outcome. Long-term survival is not achieved well.
2013, Vol. 24 
