Abstract：Objective To estimate the optimal dose of gemcitabine administered concurrently with gamma knife therapy in patients with locally advanced pancreatic cancer. Method “3+3” model was measured in the study. Eligible patients had histologically confirmed pancreatic adenocarcinoma deemed locally unresectable. Patients received gamma knife therapy (52 Gy/13F) with concurrent infused weekly gemcitabine(dose escalated from 700 mg/m2 to 900 mg/m2 weekly) until dose-restricted toxicity. Results 9 patients were enrolled. Patients enrolled in gemcitabine 700 mg/m2 and 800 mg/m2 completed the plan.III-IV degree hematology toxicity was seen in patients when gemcitabine dose escalated to 900 mg/m2. Conclutions The combination of gemcitabine and gamma knife therapy is well tolerated. The optimal dose of gemcitabine is 800 mg/m2 weekly.
俞立权,曹京旭,程海民,杨远游,史铭,宋薇,王迎选. 伽玛刀联合吉西他滨治疗局部晚期胰腺癌的Ⅰ期临床观察[J]. , 2013, 24(10): 881-883.
YU Liquan,CAO Jingxu,CHENG Haimin,YANG Yuanyou,SHI Ming,SONG Wei,and WANG Yingxuan.. A phase I study of gemcitabine combined with gamma knife therapy for locally advanced pancreatic cancer. , 2013, 24(10): 881-883.
2013, Vol. 24 
