Expression and biologic significance of EMA protein and Ki67 antigen in different stages and classification of thymoma
QUAN Liguo1,JIANG Xuedong1,WANG Qiong1,WU Yanbo2,and ZHANG Qigang3
1. Department of Thoracic Cardiovasc ular Surgery, Liaoning Provincial Corps Hospital, Chinese People’s Armed Police Forces, Shenyang 110034, China; 2. Clinic of Shenyang Warehouse, Chinese People’s Armed Police Forces, Shenyang 110021, China; 3. Department of Thoracic Surgery, First Affiliated Hospital, China Medical University, Shenyang 110001, China
Abstract：Objective To study biological characteristics, prognosis and postoperative treatment in different clinical stages and pathologic types of thymoma. Methods Expressions of epithelial membrane antigen ( EMA) and Ki67 monoclonal antibody were detected by immunohistochemistry in thymoma resection specimens of 109 cases. The expression level of these antibody was respectively observed in different Masaoka stages and WHO pathological classification of thymoma, and statistical analysis was carried out. Results In different clinical stage and pathological type patients with thymoma, EMA negative or positive expression rate had no statistically significant difference, but from clinical stage Ⅱb and B2 pathologic type, the expression intensity was gradually increased, and had the extremely significant difference ( P<0.01), differently compared with stage Ⅰ, stage Ⅱa, A type, AB type and B1 type. Since stage Ⅱb and B2 type, level Ⅲ and Ⅳ of Ki67 index increased significantly, and had very significant differonce ( P<0.01), compared with stage Ⅰ and Ⅱa and A, AB and type B1. Conclusions The thymoma from Masaoka stage Ⅱb and the WHO classification type B2 may have aggressive or malignant tendency, so postoperative adjuvant treatment measures should be taken.
全利国,姜学东,王琼,吴延波,张其刚. EMA和Ki67在不同分期及分型胸腺瘤中的表达及意义[J]. , 2013, 24(12): 1029-1031 .
QUAN Liguo,JIANG Xuedong,WANG Qiong,WU Yanbo,and ZHANG Qigang. Expression and biologic significance of EMA protein and Ki67 antigen in different stages and classification of thymoma. , 2013, 24(12): 1029-1031 .
2013, Vol. 24 
