Expression and significance of estrogen receptor and 17beta-hydroxysteroid dehydrogenase 1 in endometrial polyps
XIAO Pei1,ZHANG Cuiling2,SUN Li3,and WANG Shuhe4
1. Clinical School of Anhui Medical University, Hefei 230000, China; 2.Department of Obstetrics and Gynecology, Chinese Medicine Hospital of Linyi City, Linyi 276003, China; 3.Department of Gynecology and Obstetrics, Hefei Municipal First People’s Hospital, Hefei 230000, China; 4. Department of Gynecology and Obstetrics, Beijing Military Command General Hospital, Beijing 100700, China
Abstract：Objective To study the expressions of ER and 17β-HSD1 in endometrial polyps, and to clarify the pathogenesis of endometrial polyps in molecular level. Methods Endometrial polyps from 47 patients were taken as the study group; at the same time, normal endometrial tissue far from endometrial polyps were taken from the same 47 patients as the control group 1 and normal endometria from 50 subjects were taken as the control group 2 who underwent hysteroscopy. Immunohistochemical examination was conducted to detect ER and 17β-HSD1 expressions which were compared between the groups. Results The positive expression rate of ER in polyps group was 80.9%, which was 76.6% for 17β-HSD1. The rates were higher than those of the control group(P＜0.01). The expressions of ER and 17β-HSD1 were related to the risk of endometrial polyps(r=0.619, P＜0.01). Conclusions Excessive expressions of ER and 17β-HSD1 in premenopausal endometrial polyps may be the cause of occurrence and development of endometrial polyps.
2014, Vol. 25 
