Antihypertensive efficacy of candesartan alone or combined with Rhodiola rosea and effect on insulin resistance
ZHANG Xian1,GUO Ming2,LIU Li3,and ZHU Xu1
ZHANG Xian1, GUO Ming2, LIU Li3, and ZHU Xu1. 1.Department of Military Ward, 2. Department of No.1 Internal Medicine, 3. Medical Service. Yunnan Provincial Corps Hospital, Chinese People’s Armed Police Forces, Kunming 650111, China
Abstract：Objective To investigate antihypertensive efficacy of candesartan alone or combined with Rhodiola rosea and effect on insulin resistance index. Methods A total of 114 patients with hypertension were divided into group A: balance of candesartan 8 mg, 1/day; group B and group C received respectively candesartan and Hongjingtian injection 8 mg, 10 ml and 15 ml+10% glucose 250 ml, IV drip, 1/day.From all the patierts, before and afler treatment for three months, venous blood plasma was examinations of glucose (FPG)、insulin(FINS), calculation of insulin resistance index (HOMA-IR) and insulin sensitivity index (ISI). Results In groups B and C, antihypertensive efficacy was basically close and effect is higher than that in group A. For the improvement of the HOMA -IR and ISI, group C was better than group B, group B was superior to group A. Hypertension patients’ blood pressure before treatment, FINS and HOMA-IR levels were significantly higher after treatment, the ISI levels significantly lower after treatment (P<0.05). After 3 months of candesartan treatment, high blood pressure patients had significantly lower blood pressure, fasting glucose, FINS and lower HOMA-IR , ISI levels (P<0.05) and there were differences between the three groups. Conclusions Candesartan has certainly antihypertensive effect, and improves the HOMA-IR in hypertensive patients, and combined use of Rhodiola decreases FPG, FINS and HOMA-IR, increases ISI.For hypertension complicated with HOMA-IR, C group of clinical treatment is worthy of spread use.
2014, Vol. 25 
