Abstract：Objective To study the effect and safety of lactobacillus and enterococcus capsules in combination with PPI triple therapy on the cure rate of Helicobacter pylori (Hp). Methods 150 patients who were diagnosed as having erosive gastritis or peptic ulcer with H. pylori infection at this hospital were randomly divided into three groups: triple therapy group (group A,n=50, treated with lansoprazole 30 mg bid + amoxicillin 1.0 g bid + levofloxacin 0.5 g q.d), quadruple therapy group (group B,n=50, treated with bismuth potassium citrate 300 mg tid triple therapy), and combination treatment group (group C,n=50), treated with lactobdcillus and enterocoaus capsules 630 mg tid+triple therapy. The triple therapy and quadruple therapy groups were treated for 7 d, and the treatment group continued taking Bacillus licheniformis capsules for an additional 14 d. ResultsHp eradication rate was significantly higher in group C than in group C by both ITT analysis (86.0%vs 62.0%) and PP analysis (91.5% vs 64.4%, P<0.05);but showed no significant difference between the group C and group B both in ITT analysis (86.0% vs 84.0%) and PP analysis (91.5% vs 85.7%, P＞0.05). The clinical symptoms were improved more significantly in the group C than in group A (96.0% vs 74.0%,P<0.05); however, there was no significant difference in the percentage of patients showing symptom improvement between the group C and group B (96.0% vs 92.0%,P＞0.05). The incidence of adverse reactions was significantly lower in the group C than in the group A (4.0% vs 16.0%, P<0.05) and group B (4.0% vs 22.0%,P<0.05). Conclusions Lactobacillus and enterococcus capsules improve the eradication rate of Hp, alleviate clinical symptoms and reduce the incidence of adverse reactions in patients undergoing triple therapy.
罗俊卿,段泽星,李伟强,赵智. 双歧杆菌三联活菌胶囊联合质子泵抑制药三联根除幽门螺旋杆菌的疗效观察[J]. , 2014, 25(5): 437-439.
LUO Junqing,DUAN Zexing,LI Weiqiang,ZHAO Zhi. Efficacy of lactobacillus and enterococcus capsules combined with PPI triple therapy in eradication of Helicobacter pylori infection. , 2014, 25(5): 437-439.
2014, Vol. 25 
