Venlafaxine combined with aripiprazole tablets in treatment of somatization disorder
ZHANG Ying1,CAO Lei1,ZHOU Lei1,LIU Baichuan2
1.Department of Mental Health Division; 2.Medical Department, Jilin Provincial Corps Hospital, Chinese People’s Armed Police Forces, Changchun 130052, China
Abstract：Objective To study the venlafaxine combined with aripiprazole tablets and safety of treatment of somatization disorder. Methods Seventy-eight patients were randomly divided into treatment group (venlafaxine combined with aripiprazole tablets) and control group (venlafaxine alone), 39 cases each. In the ends of 2, 4, 6 weeks, the self-assessment lists of symptom (SCL-90) and adverse reaction scale (treatment emergent symptom scale, TESS) were used to evaluat the curative effect and adverse reactions. Results In the ends of 4 weeks, SCL-90 scores in the treatment group were higher than those in the control group, with statistically significant difference (P<0.05). TESS scores in the treatment group were significantly higher than those in the control group (P<0.05). 8 weeks, 12 weeks in the treatment group somatization, depression, anxiety and other factor scores improved significantly compared with the control group, the difference was statistically significant (P<0.05). Treatment group was 92.31%, higher than 79.49%, the difference was statistically significant (P<0.05); treatment group TESS score was 2.33?1.06, the control group was 2.12?0.96, the difference was not statistically significant (t=0.81). Conclusions Venlafaxine combined with aripiprazole tablets for treatment of somatization disorder is better than venlafaxine alone, and has good compliance.
Ladwig K H,Marten M B, Erazo N,et al. Identifying somatization disorder in a population based health exam in ation survey: psychosocial burden and genderd if ferences[J]. Psychosomatics, 2001, 42(6):511-518.
[2]
Ladwig K H,Marten M B, Erazo N,et al. Identifying somatization disorder in a population based health exam in ation survey: psychosocial burden and genderd if ferences[J]. Psychosomatics, 2001, 42(6):511-518.
2014, Vol. 25 
