Role of atosiban and naloxone in analgesic effects of oxytocin
WEI Xiaojie1,GUO Qulian2,and ZHANG Yanfeng2
1.Department of Anesthesiology, Hunan Provincial Corps Hospital,Chinese People’s Armed Police Forces, Changsha 410006,China; 2.Xiangya Hospital of Central South University, Changsha 410008,China
Abstract：Objective To study the role of atosiban and naloxone in the analgesic effects of oxytocin (OT). Methods Male SD rats were divided randomly into 2 groups, i.th group and i.c.v group. And both groups subdivided as below: N.S+OT (control group, C);atosiban + OT low, medium and high dose groups;naloxone + OT low, medium and high dose groups. And the mechanical pain threshold was tested 10 min,30 min,1 h,3 h,6 h,12 h,24 h after incision in all of the rats. Results I.th and i.c.v administration of atosiban could thoroughly inhibit the analgesia effect of OT(P<0.05); compared with control group, the pain threshold of rats with naloxone only decreased after low and medium doses of OT(P<0.05); the pain threshold had no significant differences between the high dose OT treated rats and the control group(P＞0.05). Conclusions The analgesic effect of OT can be totally inhibited by i.t.h or i.c.v atosiban, but partly depressed by naloxone.
魏小洁,郭曲练,张艳峰. Atosiban及纳洛酮对缩宫素镇痛作用的影响[J]. , 2014, 25(6): 588-590.
WEI Xiaojie,GUO Qulian,and ZHANG Yanfeng. Role of atosiban and naloxone in analgesic effects of oxytocin. , 2014, 25(6): 588-590.
2014, Vol. 25 
