青年冠心病危险因素的探讨

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摘要目的探讨青年冠心病的危险因素。方法选择2008-06至2013-03在解放军总医院门诊及住院期间收治的青年(年龄≤40岁)疑似冠心病患者855例,其中确诊为青年冠心病455例(冠心病组)和非冠心病400例(对照组)。详细采集病史,用高效液相色谱法检测血清同型半胱氨酸(homocysteine,Hcy)水平。采用单因素与多因素非条件Logistic 回归分析青年冠心病患者病因及危险因素。结果冠心病组和对照组在冠心病家族史、HDL-C、APOA1、血Hcy指标的差异均有统计学意义(P＜0.01 或P＜0.05)。多因素非条件Logistic 回归分析显示:冠心病家族史(OR=3.556,P=0.002)、Hcy(OR=1.380,P=0.001)是青年冠心病患者的独立危险因素。结论血浆Hcy水平和冠心病家族史是青年冠心病患者的危险因素。

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关键词 ：冠心病, 同型半胱氨酸, 青年, 危险因素

Abstract：Objective To study the risk factors in young patients with coronary heart disease. Methods A total of 855 patients (age≤40 years) hospitalized in this department between June 2011 and March 2013 were included in this study. Patients with definite diagnosis were as young coronary heart disease group (n=455) and other patients were as control group (n=400). Their serum homocysteine was measured by high performance liquid chromatography. The single factor analysis and multivariate logistic regression analysis were used for risk factors of young coronary heart disease. Results The serum Hcy, family history of coronary heart disease in young coronary heart disease group were all higher than those in control group(P<0.01 or P<0.05). The logistic regression analysis demonstrated that Hcy(OR=1.380,P=0.001)and history of coronary heart disease(OR=3.556,P=0.002)were all independent risk factors for young coronary heart disease patients. Conclusions High serum homocysteine and family history of CHD are independent risk factors for young CHD patients.

Key words： coronary heart disease homocystein young risk factors

收稿日期: 2013-12-24

ZTFLH:

R541.4

通讯作者: 朱航,E-mail: zhuhang301@126.com

作者简介: 全勇俊,硕士研究生,E-mail:qyongjun@yeah.net

引用本文:

全勇俊,朱航,苏小俊,王昊天,何凯,张子云,孙金燕. 青年冠心病危险因素的探讨[J]. 武警医学, 2014, 25(9): 895-897. QUAN Yongjun, ZHU Hang, SU Xiaojun, WANG Haotian, HE kai, ZHANG Ziyun, , SUN Jinyan. A study on risk factors in young patients with coronary heart disease. Med. J. Chin. Peop. Armed Poli. Forc., 2014, 25(9): 895-897.

链接本文:

http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2014/V25/I9/895

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