调节T细胞与1型糖尿病研究进展

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[1]	Ryba-Stanislawowska M, Skrzypknowska M, Mysliwiec M, et al. Loss of the balance between CD4+Foxp3+ regulatory T cells and CD4+IL17+ Th17 cells in patients with type 1 diabetes[J]. Hum Immunol,2013,74(6):701-707.
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[11]	Tai N, Yasuda H, Xiang Y, et al. IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice[J]. Clin Immunol,2011,139(3):336-349.
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[12]	Richer M J, Straka N, Fang D, et al. Regulatory T-cells protect from type 1 diabetes after induction by coxsackievirus infecton in the context of transforming growth factor-beta[J]. Diabetes,2008,57(5):1302-1311.
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[8]	Luo X, Tarbell K V, Yang H, et al. Dentritic cells with TGF-beta differentiate negative CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells[J]. Proc Natl Acad Sci USA,2007,104(8):2821-2826.
[14]	Tian L, Gao J, Hao J, et al. Reversal of new-onset diabetes through modulating inflammation and stimulating beta-cell replication in nonobese diabetic mice by adipeptidyl peptidase IV inhibitor[J]. Endocrinology,2010,151(7):3049-3060.
[9]	Petrichde L G, Fu J, Connor K J, et al. IFN-gamma and IL-10 islet-antigen-specific T cell responses in autoantibody-negative first degree relatives of patients with type 1 diabetes[J]. Diabetologia,2010,53(7):1451-1460.
[15]	Hu C, Ding H,Zhang X,et al. Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetes[J]. Diabetes,2013,62(8):2849-2858.
[10]	Shounan Y, Ming J, Jingjing W,et al. Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice[J]. Diabetes,2012,61(5):1180-1191.
[16]	Herold K C, Gitelman S E, Ehlers M R,et al. Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders[J].Diabetes,2013,62(11):3766-3774.
[11]	Tai N, Yasuda H, Xiang Y, et al. IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice[J]. Clin Immunol,2011,139(3):336-349.
[17]	Herold K C, Gitelman S, Greenbaum C, et al. Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years[J]. Clin Immunol,2009,132(2):166-173.
[12]	Richer M J, Straka N, Fang D, et al. Regulatory T-cells protect from type 1 diabetes after induction by coxsackievirus infecton in the context of transforming growth factor-beta[J]. Diabetes,2008,57(5):1302-1311.
[18]	Downes K, Marcovecchio M L, Clarke P,et al. Pasma concentrations of souble IL-2 receptor α(CD25)are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients[J]. Diabetologia,2014,57(2):366-372.
[13]	Olivieri A, Deangelis S, Dionisi S, et al. Serum transforming growth factor beta1 during diabetes development in non-obese diabetic mice and humans[J]. Clin Exp Immunol,2010,162(3):407-414.
[19]	Long S A, Cerosaletti K. Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects[J]. Diabetes,2010,59(2):407-415.
[14]	Tian L, Gao J, Hao J, et al. Reversal of new-onset diabetes through modulating inflammation and stimulating beta-cell replication in nonobese diabetic mice by adipeptidyl peptidase IV inhibitor[J]. Endocrinology,2010,151(7):3049-3060.
[20]	Johnson M C, Garland A L, Nicolson S C,et al. β-cell specific IL-2 therapy increases islet Foxp3+ Treg and suppresses type 1 diabetes in NOD mice[J]. Diabetes,2013, 62(11):3775-3784.
[15]	Hu C, Ding H,Zhang X,et al. Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetes[J]. Diabetes,2013,62(8):2849-2858.
[21]	Hartemann A, Bensimon G, Payan C A,et al. Low-dose interleukin 2 in patients with type 1 diabetes:a phase 1/2 randomised,double-blind,placebo-controlled trial[J]. Lancet Diabetes Endocrinol, 2013,1(4):295-305.
[16]	Herold K C, Gitelman S E, Ehlers M R,et al. Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders[J].Diabetes,2013,62(11):3766-3774.
[22]	Perl S, Perlman J, Weitzel R P,et al. Addition of rapamycin to anti-CD3 antibody improves long-term glycemia control in diabetic NOD mice[J].PLoS One,2013,8(6):e67189.
[17]	Herold K C, Gitelman S, Greenbaum C, et al. Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years[J]. Clin Immunol,2009,132(2):166-173.
[18]	Downes K, Marcovecchio M L, Clarke P,et al. Pasma concentrations of souble IL-2 receptor α(CD25)are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients[J]. Diabetologia,2014,57(2):366-372.
[23]	Long S A, Rieck M, Sanda S,et al. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments tregs yet transiently impairs β-cell function[J]. Diabetes,2012,61(9):2340-2348.
[24]	Hjorth M, Axelsson S, Ryden A, et al. GAD-alum treatment induces GAD65-specific CD4+CD25 high FOXP3+ cells in type 1 diabetic patients[J]. Clin Immunol,2011,138(1):117-126.
[19]	Long S A, Cerosaletti K. Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects[J]. Diabetes,2010,59(2):407-415.
[20]	Johnson M C, Garland A L, Nicolson S C,et al. β-cell specific IL-2 therapy increases islet Foxp3+ Treg and suppresses type 1 diabetes in NOD mice[J]. Diabetes,2013, 62(11):3775-3784.
[25]	Ludvigsson J, Hjorth M, Cheramy M, et al. Extened evaluation of the safty and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes:a randomized controlled trial[J]. Diabetologia,2011,54(3):634-640.
[21]	Hartemann A, Bensimon G, Payan C A,et al. Low-dose interleukin 2 in patients with type 1 diabetes:a phase 1/2 randomised,double-blind,placebo-controlled trial[J]. Lancet Diabetes Endocrinol, 2013,1(4):295-305.
[26]	Ludvigsson J, Krisky D, Casas R,et al. GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus[J]. N Eng J Med,2012,366(5):433-342.
[27]	Marek-Trzonkowska N, Mysliwiec M, Dobyszuk A, et al. Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets- Results of one year follow-up[J]. Clin Immunol,2014,153(1):23-30.
[22]	Perl S, Perlman J, Weitzel R P,et al. Addition of rapamycin to anti-CD3 antibody improves long-term glycemia control in diabetic NOD mice[J].PLoS One,2013,8(6):e67189.
[23]	Long S A, Rieck M, Sanda S,et al. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments tregs yet transiently impairs β-cell function[J]. Diabetes,2012,61(9):2340-2348.
[24]	Hjorth M, Axelsson S, Ryden A, et al. GAD-alum treatment induces GAD65-specific CD4+CD25 high FOXP3+ cells in type 1 diabetic patients[J]. Clin Immunol,2011,138(1):117-126.
[25]	Ludvigsson J, Hjorth M, Cheramy M, et al. Extened evaluation of the safty and efficacy of GAD treatment of children and adolescents with recent-onset type 1 diabetes:a randomized controlled trial[J]. Diabetologia,2011,54(3):634-640.
[26]	Ludvigsson J, Krisky D, Casas R,et al. GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus[J]. N Eng J Med,2012,366(5):433-342.
[27]	Marek-Trzonkowska N, Mysliwiec M, Dobyszuk A, et al. Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets- Results of one year follow-up[J]. Clin Immunol,2014,153(1):23-30.