Association between heart failure classification and sinus rhythm oscillation in ischemic cardiomyopathy
WU Huixiang1, WANG Wenguang2, ZHAO Bo3, YANG Mei4, LV Chunyan4, LIU Shuhua2
WU Huixiang1, WANG Wenguang2, ZHAO Bo3, YANG Mei4, LV Chunyan4, and LIU Shuhua2. 1.Department of Medicine, Qinhuangdao Orthopedics Hospital;2. Department of Cardiology, 3.Department of CT, 4.Department of Gastroenterology, Qinhuangdao First Hospital, Qinhuangdao 066000, China
Abstract：Objective To investigate the relationship between heart rate oscillation (HRT) and heart function in ischemic cardiomyopathy patients. Methods From June 2008 to December 2012, a total of 96 ischemic myocardiopathy patients with moderate to severe heart failure patients and 75 controls were enrolled in this study. According to the New York Heart Association (NYHA) classification, these patients were divided into gradeⅡ, grade Ⅲ and grade Ⅳ subgroups. We obtained 24-hour Holter ECG records to assess the HRT parameters, including turbulence onset (TO), turbulence slope (TS), and then divided patients into three groups:HRT0, HRT1, HRT2. The value of B-type natriuretic peptide (BNP), left ventricular end diastolic dimension (LVDd), and left ventricular ejection fraction (LVEF) were measured. The relationships between HRT parameters and severity of heart failure in ischemic cardiomyopathy patients were determed. Results ICM patients had higher value of TO , BNP and LVDd than controls, but the TS and LVEF values in ICM patients were lower than those in the control group(P<0.05). There were statistical differences in TS, BNP, LVDd and LVEF between the NYHA grade Ⅳ group and NYHA grade Ⅱ/Ⅲ group(P<0.05). Significant differences in TS, BNP and LVEF between patients with NYHA grade Ⅲ and NYHA grade Ⅱ were also found(P<0.05). Correlation analyses indicated that TO positively correlated with BNP, while TS positively correlated with LVEF and negtively correlated with LVDd and BNP. ICM patients with NYHA grade Ⅳ had higher HRT1/2 rate than those with NYHA grade Ⅱ/Ⅲ(P<0.05). Conclusions HRT levels may be closely related to the development and progression of ICM in patients.
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2015, Vol. 26 
