Effect of hyperuricemia on type Ⅱ cardiorenal syndrome induced
MENG Lingchong1, WANG Jing2, LIU Jianchun2
1.Medical Team, Beijing Municipal Corps Sixth Detachment, Chinese People’s Armed Police Forces, Beijing 100037, China. 2. Department of Cardiorenal Diseases, Beijing Municipal Corps Second Hospital, Chinese People’s Armed Police Forces, Beijing 100037, China
Abstract：Objective To investigate the effecthyperuricemiaon patients’of cardiac function in cardiorenal syndrome type Ⅱ. Methods 120 patients with types Ⅱcardiorenal syndrome, according to their level of serum uric acid, were divided into hyperuricemia group and normal uric acid group, and the differencesin related indexes of cardiac function were analyzed. Results Of 120 patients with type Ⅱcardiorenal syndrome, 88(73.3%) had hyperuricemia. Betweenhigh uric acid group and normal uric acid group, renal function, blood pressure, blood glucose, and blood lipid showed no statistically significant difference (P>0.05), NTproBNP in high uric acid group was (2483.7±296.5) pg/ml, left ventricular end diastolic diameter was (53.2±6.9) mm, while those in normal uric acid group were (2203.5±176.7) pg/ml and (52.9±4.8)mm,respectively the difference showed no statistical significance. Conclusions Hyperuricemia in patients with cardiorenal syndrome type Ⅱ is in highly incident, but has no effects on their cardiac function.
Juraschek S P, Tunstall-Pedoe H, Woodward M. Serum uric acid and the risk of mortality during 23 years follow-up in the Scottish Heart Health Extended Cohort Study[J]. Atherosclerosis,2014,233(2):623-629.
[2]
Ekundayo O J, Dell'italia L J, Sanders P W, et al.Association between hyperuricemia and incident heart failure among older adults: a propensity-matched study[J]. Int J Cardiol,2010,142(3):279-287.
[3]
Katz R, Sarnak M J, Newman A B, et al.Relationship of uric acid with progression of kidney disease[J]. Am J Kidney Dis,2007,50(4):239-247.
[4]
Ochiai M E, Barretto A C, Oliveira M T , et al. Uric acid renal excretion and renal insufficiency in decompensated severe heart failure[J]. Eur J Heart Fail, 2005,7(12):468-474.
[5]
Ekundayo O J, Dell'italia L J, Sanders P W, et al. Association between hyperuricemia and incident heart failure among older adults: a propensity-matched study[J]. Int J Cardiol, 2010, 142(3):279-287.
[6]
George J, Carr E, Davies J, et al. High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid[J]. Circulation,2006,11(4):2508-2516.
[7]
Desai R V, Ahmed M I, Fonarow G C, et al. Effect of serum insulin on the association between hyperuricemia and incident heart failure[J]. Am J Cardiol, 2010,106(11):1134-1138.
2015, Vol. 26 
