Abstract：Objective To compare the clinical effects of two different guided bone tissue materials β-tricalcium phosphate and coral hydroxyapatite, on socket preservation. Methods 64 patients who needed to extract mandibular molar from June 2013 to June 2014 in General Hospital of Armed Police Forces were recruited into the study. All the patients were randomly divided into four groups, with 16 teeth in each. Two groups were implanted β-TCP and CHA, respectively, after tooth extraction. The remaining groups were set as ADM and blank control group. The width and height of the alveolar ridge were measured before and 6 months after tooth extraction for statistical analysis. A trephine core biopsy of the implant socket preparation was performed in implant placement after 6 months for histological observation. Results The bone absorption of two trial groups were significantly lower than that of other two groups (P<0.05), but there was no significant difference between themselves. The group of β-TCP showed more bone formation (39.85%±6.18%, P<0.05), whereas, they were both lower than other two groups significantly (ADM: 45.15%±7.07%; blank control group: 46.37%±8.09%, P<0.05); there was no significant difference between ADM and black control groups in bone absorption (P>0.05). Conclusions Application of β-TCP and CHA combined with acellular dermal matrix for socket preservation can obtain both good effects in preserving the bone quantity. In the aspect of osteogenesis, β-TCP is better than CHA.
李常旭,王立军. 两种骨代材料在拔牙位点保存术中的临床效果[J]. 武警医学, 2015, 26(12): 1228-1231.
LI Changxu and WANG Lijun. Clinical study on two kinds of bone substitutes in socket preservation. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(12): 1228-1231.
Weng D, Stock V, Schliephake H. Are socket and ridge preservation techniques at the day of tooth extraction efficient in maintaining the tissues of the alveolar ridge?[J]. Eur J Oral Implant, 2011,4(5):59-66.
[3]
Schropp L, Wenzel A, Kostopoulos L, et al. Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study[J]. Int J Periodont Rest, 2003, 23(4): 313-324.
[2]
Gholami G A, Najafi B, Mashhadiabbas F, et al. Clinical, histologic and histomorphometric evaluation of socket preservation using a synthetic nanocrystalline hydroxyapatite in comparison with a bovine xenograft: a randomized clinical trial[J]. Clin Oral Implan RES, 2012, 23(10): 1198-1204.
[4]
Kaili L, Zheng W, Jiang C, et al. Fast and simultaneous determination of calcium and phosphorus in calcium phosphate based bioceramics by ICP-AES[J]. Key Eng Mater,2008,361(0):143-146.
[5]
Huber A R, Kunkel S L, Todd R F, et al. Regulation of transendothelial neutrophil migration by endogenous interleukin-8[J]. Science, 1991,254(5028):99-102.
[3]
Schropp L, Wenzel A, Kostopoulos L, et al. Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study[J]. Int J Periodont Rest, 2003, 23(4): 313-324.
[6]
Moed B R, Willson Carr S E, Craig J G, et al. Calcium sulfate used as bone graft substitute in acetabular fracture fixation[J]. Clin Orthop Relat Res, 2003,410(410):303-309.
[7]
Horch H H, Sader R, Pautke C, et al. Synthetic, pure-phase beta-tricalcium phosphate ceramic granules (Cerasorb) for bone regeneration in the reconstructive surgery of the jaws[J]. Int J Oral Maxillofac Surg, 2006,35(8):708-713.
[4]
Kaili L, Zheng W, Jiang C, et al. Fast and simultaneous determination of calcium and phosphorus in calcium phosphate based bioceramics by ICP-AES[J]. Key Eng Mater,2008,361(0):143-146.
[8]
Zerbo I R, Bronckers A L J J, De Lange G L, et al. Histology of human alveolar bone regeneration with a porous tricalcium phosphate[J]. Clin Oral Implants R, 2001, 12(4): 379-384.
[5]
Huber A R, Kunkel S L, Todd R F, et al. Regulation of transendothelial neutrophil migration by endogenous interleukin-8[J]. Science, 1991,254(5028):99-102.
[9]
Kenney E B, Lekovic V, Carranza F A, et al. A comparative clinical study of solid and granular porous hydroxylapatite implants in human periodontal osseous defects[J]. J Biomed Mater Res, 1988, 22(12): 1233-1243.
[6]
Moed B R, Willson Carr S E, Craig J G, et al. Calcium sulfate used as bone graft substitute in acetabular fracture fixation[J]. Clin Orthop Relat Res, 2003,410(410):303-309.
[10]
Rosen H M, McFarland M M. The biologic behavior of hydroxyapatite implanted into the maxillofacial skeleton[J]. Plast Reconstr Surg, 1990, 85(5): 718-723.
[7]
Horch H H, Sader R, Pautke C, et al. Synthetic, pure-phase beta-tricalcium phosphate ceramic granules (Cerasorb) for bone regeneration in the reconstructive surgery of the jaws[J]. Int J Oral Maxillofac Surg, 2006,35(8):708-713.
[11]
Byrd H S, Hobar P C, Shewmake K. Augmentation of the craniofacial skeleton with porous hydroxyapatite granules[J]. Plast Reconstr Surg, 1993,91(1):15-22.
[8]
Zerbo I R, Bronckers A L J J, De Lange G L, et al. Histology of human alveolar bone regeneration with a porous tricalcium phosphate[J]. Clin Oral Implants R, 2001, 12(4): 379-384.
[9]
Kenney E B, Lekovic V, Carranza F A, et al. A comparative clinical study of solid and granular porous hydroxylapatite implants in human periodontal osseous defects[J]. J Biomed Mater Res, 1988, 22(12): 1233-1243.
[12]
Stavropoulos F, Dahlin C, Ruskin J D, et al. A comparative study of barrier membranes as graft protectors in the treatment of localized bone defects[J]. Clin Oral Implan RES, 2004, 15(4): 435-442.
[10]
Rosen H M, McFarland M M. The biologic behavior of hydroxyapatite implanted into the maxillofacial skeleton[J]. Plast Reconstr Surg, 1990, 85(5): 718-723.
[11]
Byrd H S, Hobar P C, Shewmake K. Augmentation of the craniofacial skeleton with porous hydroxyapatite granules[J]. Plast Reconstr Surg, 1993,91(1):15-22.
[13]
Fernandes P G, Novaes Jr A B, de Queiroz A C, et al. Ridge preservation with acellular dermal matrix and anorganic bone matrix cell-binding peptide P-15 after tooth extraction in humans[J]. J Periodontol,2011,82(1):72-79.
[14]
Lindhe J, Cecchinato D, Donati M, et al. Ridge preservation with the use of deproteinized bovine bone mineral[J]. Clin Oral Implants R, 2014, 25(7): 786-790.
[12]
Stavropoulos F, Dahlin C, Ruskin J D, et al. A comparative study of barrier membranes as graft protectors in the treatment of localized bone defects[J]. Clin Oral Implan RES, 2004, 15(4): 435-442.
[15]
Vignoletti F, Matesanz P, Rodrigo D, et al. Surgical protocols for ridge preservation after tooth extraction. A systematic review[J]. Clin Oral Implants R, 2012, 23(s5): 22-38.
[13]
Fernandes P G, Novaes Jr A B, de Queiroz A C, et al. Ridge preservation with acellular dermal matrix and anorganic bone matrix cell-binding peptide P-15 after tooth extraction in humans[J]. J Periodontol,2011,82(1):72-79.
[14]
Lindhe J, Cecchinato D, Donati M, et al. Ridge preservation with the use of deproteinized bovine bone mineral[J]. Clin Oral Implants R, 2014, 25(7): 786-790.
[16]
Perelman-Karmon M, Kozlovsky A, Liloy R, et al. Socket site preservation using bovine bone mineral with and without a bioresorbable collagen membrane[J]. Int J Periodont Rest, 2012, 32(4):459-465.
[15]
Vignoletti F, Matesanz P, Rodrigo D, et al. Surgical protocols for ridge preservation after tooth extraction. A systematic review[J]. Clin Oral Implants R, 2012, 23(s5): 22-38.
[17]
Tiainen H, Verket A, Haugen H J, et al. Dimensional ridge preservation with a novel highly porous TiO2 scaffold: an experimental study in minipigs[J]. Int J Biomaterials, 2012, 2012,851264-851264.
[16]
Perelman-Karmon M, Kozlovsky A, Liloy R, et al. Socket site preservation using bovine bone mineral with and without a bioresorbable collagen membrane[J]. Int J Periodont Rest, 2012, 32(4):459-465.
[18]
Nemcovsky C E, Serfaty V. Alveolar ridge preservation following extraction of maxillary anterior teeth. Report on 23 consecutive cases[J]. J Periodontol, 1996, 67(4): 390-395.
[19]
Jensen S S, Yeo A, Dard M, et al. Evaluation of a novel biphasic calcium phosphate in standardized bone defects. A histologic and histomorphometric study in the mandibles of minipigs[J]. Clin Oral Implan RES, 2007, 18(6): 752-760.
[20]
Neamat A, Gawish A, Gamal-Eldeen A M. β-Tricalcium phosphate promotes cell proliferation, osteogenesis and bone regeneration in intrabony defects in dogs[J]. Arch Orak Biol, 2009, 54(12): 1083-1090.
[17]
Tiainen H, Verket A, Haugen H J, et al. Dimensional ridge preservation with a novel highly porous TiO2 scaffold: an experimental study in minipigs[J]. Int J Biomaterials, 2012, 2012,851264-851264.
Nemcovsky C E, Serfaty V. Alveolar ridge preservation following extraction of maxillary anterior teeth. Report on 23 consecutive cases[J]. J Periodontol, 1996, 67(4): 390-395.
[19]
Jensen S S, Yeo A, Dard M, et al. Evaluation of a novel biphasic calcium phosphate in standardized bone defects. A histologic and histomorphometric study in the mandibles of minipigs[J]. Clin Oral Implan RES, 2007, 18(6): 752-760.
[20]
Neamat A, Gawish A, Gamal-Eldeen A M. β-Tricalcium phosphate promotes cell proliferation, osteogenesis and bone regeneration in intrabony defects in dogs[J]. Arch Orak Biol, 2009, 54(12): 1083-1090.
2015, Vol. 26 
