应用CTA对无症状非糖尿病高危人群冠状动脉粥样硬化的研究

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摘要目的应用冠状动脉CT血管成像技术(computed tomography angiography,CTA)确定有高危因素,且非糖尿病无冠心病症状者冠状动脉粥样硬化(coronary atherosclerotic, CA)发生率,评价其与高危因素的相关性。方法在非糖尿病无冠心病症状健康查体的人群中,收集有高危因素(性别、年龄、高血压、高脂血症)者并将其分为单项高危因素组、2项及以上高危因素组。统计有高危因素者冠状动脉粥样硬化发生率。结果单因素分析发现,年龄和性别对CA的发生率有统计学差异(χ² ＝4.6,P＝0.0032,χ²＝6.5,P＝0.0108)。高危因素logistic回归分析得出,年龄与CA的发生率有相关性(OR＝1.77,CI＝1.19～2.66)。高危因素组间比较,多项高危因素CA的发生率有统计学差异(χ²＝4.44,P=0.035)。结论在非糖尿病无症状人群中,CTA能够在一次扫描提供冠状动脉斑块的重要信息,性别、年龄可能对发生CA病变带来更大的风险,作为一项无创性的检查,CTA在CA的诊断中发挥重要作用。

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	刘烨
	王耀彬
	陈天金
	温友信
	韩向东
	陈艳琼
	杨立

关键词 ：冠状动脉粥样硬化, CT血管成像, 危险因素

Abstract：Objective To make use of coronary CTA to determine the incidence rate of coronary atherosclerosis for non-diabetic asymptomatic people who have risk factors and evaluate its correlation with risk factors. Methods We recruited non-diabetic asymptomatic people who had high-risk factors (sex, age, hypertension, hyperlipidaemia) and divided them into single high-risk factor group and multiple high-risk factors group. Statistics was conducted on the incidence rate of disease for people who had high-risk factors in coronary atherosclerosis. Results Single risk factor grouping analysis showed that gender and age had significant difference in the incidence of CA(χ²＝4.6,P＝0.0032,χ²＝6.5,P＝0.0108) . For risk factors between groups, the incidence of multiple risk factors CA had significant difference (χ²＝4.6,P＝0.0032,χ²＝6.5,P＝0.0108). Logistic regression analysis showed that risk factors correlated with age and incidence of CA (OR＝1.77, CI＝1.19-2.66). Conclusions In asymptomatic non-diabetic population, CTA provides important information about coronary plaque in one scan, gender and age may have a greater risk of CA disease. As a non - invasive examination, CTA plays an important role in the diagnosis of CA.

Key words： coronary atherosclerosis CTA risk factors

收稿日期: 2015-06-12

ZTFLH:

R543

通讯作者: 杨立,E-mail:yangli301@yahoo.com E-mail: yangli301@yahoo.com

作者简介: 刘烨,硕士,主治医师,E-mail: Minnie_lmm@sina.com

引用本文:

刘烨,王耀彬,陈天金,温友信,韩向东,陈艳琼,杨立. 应用CTA对无症状非糖尿病高危人群冠状动脉粥样硬化的研究[J]. 武警医学, 2015, 26(12): 1237-1240. LIU Ye, WANG Yaobin, CHEN Tianjin, WEN Youxin, HAN Xiangdong, CHEN Yanqiong,and YANG Li. A study of computed tomography angiography (CTA) on coronary atherosclerosis in risk factors asymptomatic population. Med. J. Chin. Peop. Armed Poli. Forc., 2015, 26(12): 1237-1240.

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http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2015/V26/I12/1237

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