1. Department of Gastroenterology,Shaanxi Provincial Crops Hospital of Chinese People’s Armed Police Force, Xi’an 710054, China; 2. Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China
Abstract:Objective To study the correlation between endoscopy, pathologic characteristics and tumor invasion in early gastric cancer (EGC) by a retrospective analysis. Methods Endoscopic and clinicopathological features in 72 patients by endoscopy, pathological and post-operative EGC diagnosis were analyzed. Results Gender, age, main symptoms, differentiation, and endoscopic morphology typing of patients was not correlated with depth of invasion (P>0.05). 15 cases with submucosal tumor invasion and the lesion size diameter≥2 cm accounted for 60.00% (χ2=22.273, P=0.000, Cramer’s V coefficient=0.556). Lesion site is associated with depth of invasion (χ2=17.743, P=0.000, Cramer’s V coefficient=0.496). The upper lesion invading the submucosa accounted for 77.78%, while the middle and lower lesion invading the submucosa, only in 12 cases, accounted for 19.05%. Conclusions Lesion site and lesion size in EGC are closely related to the depth of invasion. It will provide further guidance for EGC in detection, treatment and prognosis.
Ferlay J, Shin H, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008[J]. Int J Cancer, 2010, 127(12): 2893-2917.
[2]
Qu H M,Bai Y N,Cheng N, et al. Trend analysis of cancer mortality in the Jinchang Cohort, China, 2001-2010[J]. Biomed Environ Sci, 2015, 28(5): 364-369.
[3]
Choi J, Kim S G, Im J P, et al. Long-term clinical outcomes of endoscopic resection for early gastric cancer [J]. Surg Endosc, 2015, 29(5):1223-1230.
[4]
Ali Z, Deng Y, Ma C. Progress of research in gastric cancer [J]. J Nanosci Nanotechnol, 2012, 12(11): 8241-8248.
[5]
Chiu P W. Novel endoscopic therapeutics for early gastric cancer [J]. Clin Gastroenterol Hepatol, 2014, 12(1): 120-125.
[6]
Participants in the Paris Workshop. The Paris endoscopic classification of superficial neoplastic lesions: esophagus,stomach, and colon: November 30 to December 1, 2002 [J]. Gastrointest Endos, 2003, 58(6 Suppl): S3-S43.
[7]
Li Z, Li Q. The latest 2010 WHO classification of tumors of digestive system [J]. Zhonghua Bing Li Xue Za Zhi, 2011, 40(5): 351-354.
[8]
De Martel C, Forman D, Plummer M. Gastric cancer epidemiology and risk factors [J]. Gastroenterol Clin North Am, 2013, 42(2): 219-240.
[9]
Dawood S. Updates from Gastrointestinal ASCO 2015[J]. Indian J Med Paediatr Oncol, 2015, 36(2): 133-136.
[10]
Gotoda T, Jung H Y. Endoscopic resection (endoscopic mucosal resection/ endoscopic submucosal dissection) for early gastric cancer [J]. Dig Endosc, 2013, 25(Suppl 1): 55-63.
[11]
Zhao B W, Chen Y M, Jiang S S, et al. Lymph node metastasis, a unique independent prognostic factor in early gastric cancer[J]. PLoS One, 2015, 10(7): e0129531.
[12]
Shin N, Jeon T Y, Kim G H, et al. Unveiling lymph node metastasis in early gastric cancer[J]. World J Gastroenterol, 2014, 20(18): 5389-5395.
[13]
Kim D Y, Joo J K, Ryu S Y, et al. Factors related to lymph node metastasis and surgical strategy used to treat early gastric carcinoma [J]. World J Gastroenterol, 2004, 10(5): 737-740.