Effects of different training modes on plasma creatine kinase and cell-free plasma DNA in soldiers of PAP
PENG Peng1, BO Hai1, WANG Daning1, DIAO Qiuxia1, ZHANG Lei2, and QIN Yongsheng1
1. Department of Military Training Medicine, 2. Department of Basic Teaching of Military Common Subjects, Logistics University of Chinese People’s Armed Police Force, Tianjin 300309, China
Abstract：Objective To study the effect of different training modes on plasma creatine kinase (CK) and cell-free plasma DNA (cf-DNA) in soldiers of PAP and sought sensitive marker of early diagnosis of exercise-induced fatigue and muscle injury in military training. Methods Forty-five soldiers of PAP were randomly divided into three groups: aerobic training group (5 km running), concentric strength training group (push-up and sit-ups) and eccentric strength training group (squatting-jump on-the-spot and leapfrog). Plasma creatine kinase (CK) and cf-DNA were determined pre-training, immediate post-training, 30 min, 1 h, 12 h and 24 h after training, respectively. Results Plasma CK and cf-DNA in aerobic training group were not changed significantly at all time-points (P>0.05). Plasma CK of concentric strength training group was significantly elevated 12 h post-training [(315±95) vs (134±45) IU/L, P<0.01] and recovered at 24 h [(151±71) vs (134±45) IU/L, P>0.05]; cf-DNA was significantly raised immediately after training [(59.1±12.7) vs (43.4±8.0) pg/μl, P<0.05], reached peak value 30 min post-training [(95.3±13.6) vs (43.4±8.0) pg/μl, P<0.01] and restored to base-line at 12 h [(47.7±10.9) vs (43.4±8.0) pg/μl, P>0.05]. Time course changes in plasma CK and cf-DNA of eccentric strength training group were similar to those in concentric strength training group, but elevation extent was significantly higher than that in latter (P<0.01). Conclusions The response of cf-DNA to exercise is dependent on the training modes. Aerobic training of middle intensity does not influence cf-DNA but strength training especially eccentric strength training can significantly impact cf-DNA. cf-DNA may be a sensitive marker for early diagnosis of exercise-induced fatigue and exercise induced muscle injury in military training.
彭朋, 薄海, 王大宁, 刁秋霞, 张磊, 秦永生. 不同训练方式对武警战士血浆肌酸激酶和血浆游离DNA的影响[J]. 武警医学, 2016, 27(3): 268-271.
PENG Peng, BO Hai, WANG Daning, DIAO Qiuxia, ZHANG Lei, and QIN Yongsheng. Effects of different training modes on plasma creatine kinase and cell-free plasma DNA in soldiers of PAP. Med. J. Chin. Peop. Armed Poli. Forc., 2016, 27(3): 268-271.
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2016, Vol. 27 
