Abstract：Objective To evaluate the value of serum collagen peptide (CY21-1), carbohydrate antigen 72-4 (CA72-4), neuron specific enolase (NSE), squamous epithelial cell carcinoma antigen (SCC), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA),such six kinds of serum tumor markers(TM) in auxiliary diagnosis of lung cancer.Methods With electrochemical immunoassay assay,serum levels of CY21-1,NSE,SCC,CEA,CA72-4 and CAl25 were detected in 245 patients with lung cancer and 138 healthy people.Results The levels of serum tumor markers in lung cancer group were statistically significantly different from those in healthy group (P<0.05). When the specificity was 95%, the diagnostic sensitivity of CY21-1 for squamous cell carcinoma was 78.87%,that of CEA for diagnosis of adenocarcinoma was 70.75%, that of NSE for diagnosis of small cells carcinoma was 91.18%.The diagnostic sensitivity of 6 kinds of tumor markers combined detection of squamous cell carcinoma, adenocarcinoma and small cell carcinoma were 91.55%, 86.79% and 95.59%, respectively.Conclusions The diagnostic value of NSE,CY21-1 and CEA are high in small cell carcinoma,squamous cell carcinoma and adenocarcinoma. Combined detection of multiple tumor markers can improve the sensitivity of diagnosis of lung cancer.
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2016, Vol. 27 
