Abstract：Objective To explore the diagnostic and prognostic value of glycogen phosphorylase BB(GPBB) in patients of non-ST elevation acute coronary syndromes(NSTE ACS).Methods Levels of GPBB and cTnI were measured in 83 patients with unstable angina pectoris(UAP) and 72 non-ST-elevation myocardial infarction (NSTE MI) before the data were analyzed with receiver operating characteristic curve(ROC curve) statistical software. Major adverse cardiac events were observed in 98 NSTE ACS patients after 3 years of follow-up.Results The GPBB value at 6h after chest pain of NSTE MI group and UAP group was 7.364±5.452 μg/L and 1.118±0.860 μg/L respectively, but was 8.045±4.934 μg/L and 0.849±0.589 μg/L respectively at 12h. The difference were statistically significant (P<0.001).The area under the ROC curve , sensitivity , and specificity of GPBB at 6h after chest pain when the optimal cutoff value was 0.92 μg/L in the diagnosis of NSTE MI were 0.845, 77.8% and 89.2% respectively, but were 0.912, 84.7% and 91.6% respectively at 12 h, while those of cTnI at 6 h after chest pain when the optimal cutoff value was 0.48 μg/L in the diagnosis of NSTE MI were 0.816, 63.9% and 89.2% respectively, but were 0.936, 90.3% and 91.6% respectively at 12 h. High GPBB had a strong association with the risk of major adverse cardiac events through 3 years of follow-up.Conclusions GPBB is a more sensitive marker of NSTE MI than cTnI at 6 h after chest pain and of clinical value for prognosis of NSTE ACS.
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