Clinical comparative study of intensity-modulated radiotherapy and gamma knife combined with TACE for the treatment of primary hepatic carcinoma
ZHANG Yu1,CHEN Shaoshui2,LI Gong1,LIU Changmin2, LI Guangxin3
1.Cancer Second Division,General Hospital of Chinese People’s Armed Police Force,Beijing 100039,China; 2.Cancer Division,Affiliated Hospital of Binzhou Medical Oncology,Binzhou 256600,China 3. Cancer Division, Third Hospital of Beijing Municipal Corps,Chinese People’s Armed Police Force, Beijing 100049,China
Abstract：Objective To compare the clinical curative effect of the gamma knife (γ knife) and intensity-modulated radiotherapy(IMRT) combined with transcatheter hepaticarterial chemoembolization (TACE) for primary hepatic carcinoma.Methods According to the stochastic indicator, 94 cases of PHC patients betweem March 2012 and June 2014 were equally divided into control group and observation group. Patients in control group were treated with intensity-modulated radiotherapy combined with TACE, while observation group was treated with γ knife combined with TACE. The recent and forward curative effect, occurrence of adverse reactions of drugs and the level of serum alpha fetal protein (AFP) of the two groups were analyzed comparatively.Results After one-month treatment, the effective rate of observation group was 82.98% (39/47), which was obviously higher than that of control group[57.45% (27/47)], and the difference was statistically significant (P<0.05). The level of serum AFP of the two groups declined obviously after treatment, and thatof observation group was significantly lower than in control group. The difference was statistically significant (P<0.05 or P<0.01). The incidence of adverse reactions in observation group was 14.89% (7/47), which was significantly lower than in control group[25.53% (12/47)], and the difference was statistically significant (P<0.05). However, the difference of survival rate after 6 months and 12 months of treatment between the two groups was not of statistical significance (P>0.05). The survival rate of observation group after 24 months of treatment was significantly higher than that of control group (P<0.05).Conclusions Compared with intensity-modulated radiotherapy combined with TACE, γ knife combined with TACE for the treatment of primary hepatic carcinoma has a better recent and forward curative effect in that it can not only reduce the incidence of toxic reactions of drugs effectively, but significantly inhibit the level of serum AFP, which is worthy of clinical popularization and application.
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ZHANG Yu,CHEN Shaoshui,LI Gong,LIU Changmin, LI Guangxin. Clinical comparative study of intensity-modulated radiotherapy and gamma knife combined with TACE for the treatment of primary hepatic carcinoma. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(1): 68-71.
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2017, Vol. 28 
