复方倍他米松联合透明质酸钠在退行性半月板损伤手术中的应用

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摘要目的探讨复方倍他米松联合透明质酸钠在退行性半月板损伤手术中的应用。方法选择我院2014-01至2015-12收治的49例退行性半月板损伤患者(观察组),采用复方倍他米松联合透明质酸钠治疗方案,另选择我院2012-06至2013-12收治的45例退行性半月板损伤患者(对照组),采用单纯注射透明质酸钠的治疗方案,观察两组治疗效果。结果观察组总有效率为93.9%,对照组为82.2%,观察组优于对照组(P＜0.05);治疗前IKDC评分无统计学差异,治疗6个月后,观察组IKCK评分(76.1±9.8)分,对照组为(61.9±7.7)分,观察组优于对照组(P＜0.05);治疗前Lysholm评分无统计学差异,治疗6个月后,观察组Lysholm评分(87.8±8.6)分,对照组为 (71.1±6.9)分,观察组优于对照组(P＜0.05);治疗6个月后,对照组和观察组血清NO、IL-1β水平均较治疗前显著降低(P＜0.05),但观察组改善更为显著(P＜0.05)。结论复方倍他米松联合透明质酸钠治疗退行性半月板损伤效果优于单用透明质酸钠。

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	葛茂林
	王晓红
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	任娜

关键词 ：复方倍他米松, 透明质酸钠, 退行性半月板损伤

Abstract：Objective To evaluate the efficacy of compound betamethasone combined with sodium hyaluronate in the treatment of degenerative meniscus injury.Methods Forty-nine patients with degenerative meniscus injury (observation group) were treated with compound betamethasone combined with sodium hyaluronate in our hospital from Jan 2014 to Dec 2015. Another 45 patients with degenerative meniscus injury (control group) had been treated with simple sodium hyaluronate injection between June 2012 and December 2013. The therapeutic effect of the two groups was observed.Results The total effective rate(93.9%) in the observation group was better than that (82.2%) in the control group (P<0.05). There was no statistical differences in the IKDC score between the two groups before the treatment (P>0.05). After 6 months, the IKCK score (76.1±9.8)in the observation group was better than that (61.9±7.7) in the control group(P<0.05). There was no significant difference in Lysholm score between the two groups before the treatment (P>0.05). After 6 months of treatment, the Lysholm score (87.8±8.6) in the observation group was significantly higher than that (71.1±6.9)in the control group (P<0.05). After 6 months, The levels of serum NO and IL-1β in control group and observation group were significantly lower than before the treatment (P<0.05).The levels of NO and IL-1β inobservation groupwas better than that in control group (P<0.05).Conclusions Compound betamethasone combined with sodium hyaluronate is superior to sodium hyaluronate alone in the treatment of degenerative meniscus injury.

Key words： compound betamethasone sodium hyaluronate degenerative meniscus injury

收稿日期: 2016-11-07

ZTFLH:

R684.7

通讯作者: 任娜,E-mail:173786336@qq.com

作者简介: 葛茂林 ,硕士,主治医师。

引用本文:

葛茂林,王晓红,云文科,任娜. 复方倍他米松联合透明质酸钠在退行性半月板损伤手术中的应用[J]. 武警医学, 2017, 28(1): 72-74. GE Maolin, WANG Xiaohong, YUN Wenke, and REN Na. Therapeutic effect of compound betamethasone combined with sodium hyaluronate on degenerative meniscus injury. Med. J. Chin. Peop. Armed Poli. Forc., 2017, 28(1): 72-74.

链接本文:

http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2017/V28/I1/72

[1]	唐进,吉明,廖乙名,等.盘状半月板损伤修复:关节镜下缝合成形结合玻璃酸钠注射 [J]. 中国组织工程研究,2015,37(9):5943-5949.
[2]	刘俊阳,张卓,马连君,等.关节镜术后玻璃酸钠关节内注射治疗半月板损伤伴骨关节炎的疗效[J].中国老年学杂志,2012,32(23):5327-5328.
[3]	唐宏超. 透明质酸关节腔内注射在半月板损伤关节镜术后应用效果[J]. 中国医药导报,2015,33(6):117-120.
[4]	陈巧,朱丹平. 透明质酸钠联合曲安奈德关节腔内注射治疗颞下颌关节骨关节病的临床疗效[J]. 中国医药指南,2015,30(7):109-110.
[5]	王荣. 透明质酸钠膝关节腔内注射治疗骨关节病的疗效观察及护理[J]. 中国医院用药评价与分析,2016,4(2):446-448.
[6]	高宗强,郭雄,陈群长,等.透明质酸对体外培养的大骨节病和骨关节炎软骨细胞透明质酸合成酶2 mRNA表达的影响[J].中国全科医学,2014,17(30):3757-3758.
[7]	陆艳红,石晓兵.膝骨关节炎国内外流行病学研究现状及进展[J].中国中医骨伤科杂志,2012,24(6):81-84.
[8]	高宗强,郭雄,陈君长,等.大骨节病、骨关节炎软骨细胞分泌IL-1β、TNF-α及透明质酸对其影响实验研究[J].陕西医学杂志,2015,44(7):774-778.
[9]	李化光,杨新明,刘华,等.透明质酸对人骨关节炎软骨细胞保护机制的探讨[J].实用医学杂志,2012,28(7):1040-1042.
[10]	李宏宙.透明质酸钠、复方倍他米松联合应用对骨性关节炎的临床效果和病理特征分析[D].天津:天津医科大学,2014:6-13.
[11]	刘丹,高大龙,李若飞,等. 血清TNF-α、IL-1β、NO水平在成人大骨节病手术治疗中的研究[J]. 中国地方病防治杂志,2013,2(8):125-126.
[12]	Killian M L,Haut R C,Haut Donahue T L. Acute cell viability and nitric oxide release in lateral menisci following closed-joint knee injury in a lapine model of post-traumatic osteoarthritis[J]. BMC Musculoskelet Disord,2014,6,15:297.
[13]	Genemaras A A,Ennis H,Kaplan L,et al. Inflammatory cytokines induce specific time-and concentration-dependent MicroRNA release by chondrocytes, synoviocytes, and meniscus cells[J]. J Orthop Res,2016,34(5):779-790.