Abstract：Objective To explore the impact of MMP-9 on cerebral edema formation in the late stage of hypertensive cerebral hemorrhage (HCH) and on clinical treatment.Methods The clinical data on 112 patients treated at the Department of Cerebral Surgery of our hospital between June 2014 and May 2016 was reviewed.Among these patients, 56 were treated with +MMP inhibitors(the experimental group) and the rest received routine treatment(the control group). Changes of the cerebral edema volume、MMP-9、neurological deficit score (NIHSS) and the total efficacy rate of treatment were compared between the two groups after two weeks of treatment.Results After two weeks of treatment, the volume of brain edema in the experimental group was (5.8±3.1) cm3, MMP-9 (61.3±21.9) μg/l and NIHSS score was (7.1±3.7), compared with (12.5±3.4) cm3, (98.2±25.4) μg/l and (13.2±4.3) respectively in the control group, so the difference was statistically significant (P<0.01 ). Moreover,the experimental group had a higher total efficacy rate than the control group (85.71%vs 64.29%,P＜0.01).Conclusions Conventional treatment comnbined with MMP-9 can improve the clinical efficacy in the late stage of HCH brain edema patients, which indirectly suggests that MMP-9 can promote the formation of cerebral edema in the late stage of cerebral hemorrhage.
Aghaei I,Bakhshayesh B,Ramezani H,et al.Therelationship between the serum levels of ferritin and theradiological brain injury indices in patients with spontaneous intracerebral hemorrhage[J].Iran J Basic Med Sci,2014,17(10): 729.
[2]
王艳春.TLR4拮抗剂减轻小鼠脑出血的炎性反应损伤机制[D].重庆:第三军医大学,2013.
[3]
Jin R,Yang G,Li G. Molecular insights and therapeutic targets forblood-brain barrier disruption in ischemic stroke:critical role ofmatrix metalloproteinases and tissue-type plasminogen activator[J]. Neurobiol Dis,2010,38(3):376-385.
[4]
Xue M,Hollenberg M D,Yong V W,et al. Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice[J]. J Neurosci,2006,26(40):10281-10291.
[5]
Skjolding A D, Rowland I J, Søgaard L V, et al. Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 in human and rat hydrocephalic brain[J].Neuropathology, 2013, 39(2):179.
Florczak R M,Grond G C,Montaner J,et al. Matrix metalloproteinases in human spontaneous intracerebral hemorrhage:an update[J]. Cerebrovasc Dis,2012,34(4):249-262.
[10]
Rosell A,Ortega A,Alvarez J, et al. Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke[J]. Stroke,2006,37(6):1399-1406.
[11]
Cui J J,Wang D,Gao F, et al.Effects of atorvastatin on pathological changes in brain tissue and plasma MMP-9 in rats with intracerebral hemorrhage[J]. Cell Biochem Biophys,2012,62(1):87-90.
Yang J,Lin S,Zhou J,et al.Genetic variations of MMP-9 gene and intracerebral hemorrhage outcome: a cohort study in Chinese Han population[J]. J Neurol Sci,2014, 343 (1):56-59.
2018, Vol. 29 
