Effect of blood cholesterol levels on survival of patients with multiple myeloma
DONG Yuehua1, LIANG Yan2, YAN Huaining3
1.Department of Internal Medicine, Beijing Municipal Corps Hospital of PAP, Beijing 100027, China; 2.Pharmacy,the Third Medical Center of Chinese PLA General Hospital,Beijing 100039, China; 3.Jiangsu Provincial Corps Hospital, Chinese People’s Armed Police Force, Yangzhou 225003, China
Abstract：Objective To explore the effects of blood cholesterol levels on the survival of patients with multiple myeloma.Methods One hundred and thirty-six patients with multiple myeloma who were treated in the hospital between June 2014 and September 2017 were selected as the observation group, while another eighty-two healthy physical examinees were selected as the control group. Relevant data was collected and retrospectively analyzed.Results Serum levels of total cholesterol [(2.67±1.12) mmol/L], low-density lipoprotein [(1.62±0.98) mmol/L], apolipoprotein B [(0.45±0.28) mmol/L] and high-density lipoprotein [(0.81±0.28) mmol/L] were significantly lower in the observation group than in the control group (P<0.05). The survival rate of stage Ⅲ patients was significantly lower than that of stage Ⅰ and stage Ⅱ patients (P<0.05). Low-density lipoprotein levels [(1.38±0.56) mmol/L] were the lowest in patients with IgA multiple myeloma, but [(2.25±0.43) mmol/L] were the highest in patients with light-chain multiple myeloma (P<0.05).Conclusion The development and survival of multiple myeloma are closely related to blood cholesterol levels that depend on the intake of low-density lipoprotein. Low blood cholesterol levels can lead to the deterioration of a patient’s condition and drug resistance, which negatively affects patients’ survival and quality of life.
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2019, Vol. 30 
