Abstract：Objective To observe the clinical effect of absorbable collagen repair combined with silver ion dressing in the treatment of skin donor wounds. Methods One hundred patients receiving autologous skin grafting were randomly divided into the treatment group and control group, with 50 cases in each. The treatment group received absorbable repair collagen combined with silver ion dressing to treat the donor site wounds, while the control group received traditional vaseline gauze treatment. The degree of pain during dressing change, wound infection rate, wound healing time, and the scar index after wound healing were observed.Results The pain during wound dressing in the treatment group was significantly less acute than in the control group ( 6.24±2.23,4.13±2.37,1.49±1.31 vs 7.73±2.14,5.24±1.59,2.43±1.66 at 3, 6, 9 days post surgery). The wound infection rate in the treatment group was 2%, which was significantly lower than 14% in the control group. The wound healing time was significantly reduced in the treatment group as compared to the control group. The degree of scar hyperplasia after wound healing was remarkedly ameliorated. Vancouver scar scores were 3.34±3.27,3.89±3.48 and 3.63±4.87 at 3, 6, 9 months post wound healing in the treatment group vs. 8.31±3.75,9.32±4.27 and 8.06±4.98 in the control group.Conclusions The absorbable repair collagen combined with silver ion dressing for the treatment of donor site wounds is superior to the traditional vaseline gauze treatment, which should be made more accessible.
邹晓防, 肖孟景, 李宝龙, 吴世建, 李斌. 可吸收修复胶原联合银离子敷料治疗供皮区创面的疗效[J]. 武警医学, 2019, 30(7): 576-579.
FANG Mingsheng, SUN Yurui, LI Yingya. Absorbable repair collagen combined with silver ion dressing in the treatment of donor site wounds. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(7): 576-579.
Schulz A, Rothermund I, Lefering R, et al. Long-term scar quality after treatment of standardized partial-thickness skin graft donor sites [J]. Adv Skin Wound Care,2018,31(3):109-117.
Nuutila K, Kankuri E, Vuola J. Donor site healing dynamics: molecular, histological, and noninvasive imaging assessment in a porcine model [J]. J Burn Care Res,2015,36(2):e104.
[4]
Rennekampff H O, Rabbels J, Reinhard V, et al. Comparing the vancouver scar scale with the cutometer in the assessment of donor site wounds treated with various dressings in a randomized trial [J]. J Burn Care Res,2006,27(3):345-351.
[5]
Bian Y, Sun C, Zhang X, et al. Wound-healing improvement by resurfacing split-thickness skin donor sites with thin split-thickness grafting [J]. Burns,2016,42(1):123-130.
[6]
McBride C A, Kimble R M, Stockton K. Three donor site dressings in pediatric split-thickness skin grafts: study protocol for a randomised controlled trial [J]. Trials,2015,16(43): 1-8.
[7]
Vaghardoost R, Momeni M, Kazemikhoo N, et al. Effect of low-level laser therapy on the healing process of donor site in patients with grade 3 burn ulcer after skin graft surgery (a randomized clinical trial) [J]. Lasers Med Sci,2018,33(3):603-607.
[8]
Miyanaga T, Haseda Y, Sakagami A. Minced skin grafting for promoting epithelialization of the donor site after split-thickness skin grafting [J]. Burns,2017,43(4):819-823.
[9]
Goverman J, Kraft CT, Fagan S, et al. Back grafting the split-thickness skin graft donor site [J]. J Burn Care Res,2017,38(1):e443-e449.
[10]
Schulz A, Depner C, Lefering R, et al. A prospective clinical trial comparing Biobrane((R)) Dressilk((R)) and PolyMem((R)) dressings on partial-thickness skin graft donor sites [J]. Burns,2016,42(2):345-355.
[11]
Karti O, Zengin M O, Cinar E, et al. Effect of 1- and 6-hour-delayed corneal collagen cross-linking on corneal healing in a rabbit alkali-burn model: clinical and histological observations [J]. Cornea,2016,35(12):1644-1649.
[12]
Ju H W, Lee O J, Lee J M, et al. Wound healing effect of electrospun silk fibroin nanomatrix in burn-model [J]. Int J Biol Macromol,2016,85: 29-39.
[13]
Nuutila K, Peura M, Suomela S, et al. Recombinant human collagen III gel for transplantation of autologous skin cells in porcine full-thickness wounds [J]. J Tissue Eng Regen Med,2015,9(12):1386-1393.
[14]
Hirche C, Senghaas A, Fischer S, et al. Novel use of a flowable collagen-glycosaminoglycan matrix (Integra Flowable Wound Matrix) combined with percutaneous cannula scar tissue release in treatment of post-burn malfunction of the hand--A preliminary 6 month follow-up [J]. Burns,2016,42(1):e1-e7.
[15]
Guo R, Lan Y, Xue W, et al. Collagen-cellulose nanocrystal scaffolds containing curcumin-loaded microspheres on infected full-thickness burns repair [J]. J Tissue Eng Regen Med,2017,11(12):3544-3555.
Haith L R, Stair-Buchmann M E, Ackerman B H, et al. Evaluation of aquacel ag for autogenous skin donor sites [J]. J Burn Care Res,2015,36(6):602-606.
[18]
Sinha S, Schreiner A J, Biernaskie J, et al. Treating pain on skin graft donor sites: Review and clinical recommendations [J]. J Trauma Acute Care Surg,2017,83(5):954-964.
[19]
Hakkarainen T, Koivuniemi R, Kosonen M, et al. Nanofibrillar cellulose wound dressing in skin graft donor site treatment [J]. J Control Release,2016,244:292-301.
[20]
Dai L G, Fu K Y, Hsieh P S, et al. Evaluation of wound healing efficacy of an antimicrobial spray dressing at skin donor sites [J]. Wounds,2015,27(8):224-228.
2019, Vol. 30 
