Abstract：Objective To compare the effects of different blood purification modalities on the micro-inflammatory status in maintenance hemodialysis(MHD) patients.Methods A total of 140 patients were equally randomized into four groups to receive 12-month blood purification treatment with hemodialysis (HD),hemoperfusion(HP), high-flow hemodialysis(HFD) and hemodiafiltration(HDF) respectively. Pre- and post-treatment serum concentrations of micro-inflammatory indexes including serum C-reactive protein(CRP),interlerkin-6(IL-6), tumornecrosis factors α(TNF-α), procalcitonin(PCT), serum creatinine(SCR), blood urea nitrogen(BUN), β2-microglobulin(β2-MG), homocysteine(Hcy) and intact parathyroid hormone(iPTH) were determined and compared.Results The levels of inflammatory response factors(CRP,IL-6, TNF-α and PCT) were significantly increased (P<0.05) after treatment, and were significantly higher in HDF and HFD groups than those in HD and HP groups(P<0.05), but no significant difference of the four indexes was found between the HFD group and the HDF group. The levels of uremic toxins(iPTH、Hcy、β2-MG) after treatment were significantly reduced in HP,HDF and HFD groups (P<0.05), and were significantly lower in HP,HDF and HFD groups than those in the HD group(P<0.05).Moreover, the levels of iPTH、Hcy and β2-MG after treatment were significantly lower in HDF and HFD groups than those in the HP group(P<0.05), but no significant difference of these uremic toxins was found between the HFD group and the HDF group.Conclusions Both HFD and HDP can adequately eliminate large or moderate toxin molecules in patients with MHD and improve the micro-inflammatory status of uremic patients significantly, but no significant difference has been found between these two groups in terms of therapeutic effect.
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2019, Vol. 30 
