Abstract：Objective To investigate the change of serum retinol binding protein 4 (RBP-4)levels in obese pregnant women and pregnant women with GDM.Methods Serum RBP-4 and APN levels were detected by Enzyme-Linked Immnno Sorbent Assay(ELISA)in 32 cases of GDM with obesity(BMI＞28 kg/m2,Group A),30 cases of GDM with normal weight(BMI 18.5-23.9 kg/m2,Group B),29 cases of obese pregnant women without pregnancy complications(BMI＞28 kg/m2,Group C) and 27 cases of normal-weight pregnant women(BMI 18.5-23.9 kg/m2,Group D).Meanwhile, FPG and TG were measured. Insulin resistance was estimated using the homeostatic model assessment insulin resistance (HOMA-IR) index.Results (1)Serum RBP 4 levels in Group A were significantly higher than those of the other three groups. RBP 4 levels in Group C were higher than those of Group B and Group D (P<0.05). (2)There was a significant positive correlation between RBP4 levels and pregnant BMI,FINS,TG and HOMA-IR,but a negative correlation between RBP-4 and APN (r value was 0.562, 0.409, 0.584, 0.618 and -0.412 respectively, P<0.05).Conclusions Serum RBP-4 levels in Groups A, B and C were significantly higher than those of Group D. Serum RBP-4 levels are significantly elevated in obese women,and closely related to obesity.
程策,王雅慧,赵霞,王国英,纪巧莹,刘君,王素影. 血清RBP-4水平与妊娠肥胖、妊娠糖尿病的关系[J]. 武警医学, 2019, 30(8): 684-686.
CHENG Ce, WANG Yahui, ZHAO Xia, WANG Guoying, JI Qiaoying, LIU Jun and WANG Suying. Relationships between serum retinol binding protein-4 levels and gestational obesity and GDM. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(8): 684-686.
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