某部队医院铜绿假单胞菌的分布和耐药性调查

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摘要目的分析医院铜绿假单胞菌的临床分布及其耐药性,加强重点区域的防控,为临床合理用药提供依据。方法回顾性分析医院2018-01至2018-12住院患者临床标本中分离出铜绿假单胞菌的来源及分布特征,统计分析药敏试验结果。结果共检出160株铜绿假单胞菌,从痰标本中分离得到的铜绿假单胞菌最多,为131株(占81.88%)。检出率排名前三位的为神外科53株、ICU48株、呼吸科13株。药敏结果显示,对多黏菌素B最敏感,敏感率为95.0%;对替卡西林/克拉维酸的耐药率最高,为51.2%。结论铜绿假单胞菌对多黏菌素B、头孢哌酮/舒巴坦、阿米卡星较敏感,应加强对铜绿假单胞菌的耐药性监测,强化临床用药的合理性,针对耐药机制寻找新的抗菌途径。

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	王楠
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关键词 ：铜绿假单胞菌, 临床分布, 耐药性, 碳青霉稀类, 多黏菌素B

Abstract：Objective To investigate the clinical distribution and drug resistance of Pseudomonas aeruginosa in order to provide evidence and reference for clinical prevention and treatment.Methods Strains of Pseudomonas aeruginosa were isolated and tested for sensitivity in 2018.Results A total of 160 clinical isolates were collected. The main source of the samples was sputum, which accounted for 81.88%. Pseudomonas aeruginosa infections mainly occurred in the Department of Neurosurgery (53 strains), ICU (48 strains) and Department of Respiratory Disease (13 strains). The 160 strains of pseudomonas aeruginosa were mostly susceptible to polymyxin B (susceptible rate 95.0%), but resistant to ticarcillin/clavulanic acid (resistance rate 51.2%).Conclusions Pseudomonas aeruginosa is susceptible to polymyxin B, cefoperazone/sulbactam and amikacin. Drug resistance of Pseudomonas aeruginosa should be monitored in order to select the right antibiotics in clinic.

Key words： Pseudomonas aeruginosa clinical distribution drug resistance carbapenem polymyxin B

收稿日期: 2019-01-24

ZTFLH:

R378

通讯作者: 王淑芳,E-mail:wshfxyz@163.com

作者简介: 王楠,硕士研究生,主管药师。

引用本文:

王楠,张翠,薛婧. 某部队医院铜绿假单胞菌的分布和耐药性调查[J]. 武警医学, 2019, 30(8): 690-692. WANG Nan, ZHANG Cui, and XUE Jing. Distribution and drug resistance of Pseudomonas aeruginosa in a military hospital. Med. J. Chin. Peop. Armed Poli. Forc., 2019, 30(8): 690-692.

链接本文:

http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2019/V30/I8/690

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