Abstract：Objective To analyze the regularity of dynamic changes of such inflammatory indexes as PCT and CRP and the changes of T-lymphocyte subsets in patients with hemorrhagic fever of renal syndrome(HFRS).Methods Data on the history of epidemiology, levels of PCT, CRP and T-lymphocyte subsets of patients with HFRS treated between 2011 and 2014 was collected for statistical analysis.Results Ninety-one patients with HFRS were included in this study. PCT and CRP levels increased significantly in the early stage, gradually declined in the polyuria phase and recovery phase. The more severe the disease was, the higher the levels of PCT and CRP were. During the early, middle and late stages, the difference in PCT was statistically significant (P<0.001). The difference in PCT between different groups of patients was also statistically significant (P<0.05). The difference of CRP was statistically significant between the three stages(P<0.001). With the exception of the severe type and critically severe group, the difference of CRP between the other groups was statistically significant (P<0.05). In the early stage of HFRS, the number of CD4+T lymphocytes was decreased while the number of CD8+T cells was increased, and the CD4/CD8 ratio was reduced.Conclusions Early detection of PCT and CRP may help to assess the severity of disease. The possible ratio imbalance in T-lymphocyte subsets in patients with hemorrhagic fever of renal syndrome may provide useful information for clinicians in the assessment and prognosis of disease.
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2019, Vol. 30 
