Effect and mechanism of ellagic acid on muscle function improvement in mice
LU Yuting1, LI Jun2, ZHOU Xianjie1, LV Yuxia1, LU Feixiang3, LIU Qingchun1
1.Procurement Center Office,the Third Medical Center of PLA General Hospital,Beijing 100039,China; 2.Laboratory Animal Center,Peking University,Beijing 100871,China; 3.Department of Laboratory Animals,Capital Medical University, Beijing 100069,China
Abstract：Objective To observe the effect of ellagic acid(EA) on muscle function in normal mice.Methods ICR male mice were randomly divided into the control group and EA treatment group, with 8 mice in each. The EA treatment group was given 10 mg/100 g weight of EA per day while the control group was given an equal volume of solvent once daily for 21 days. The Echo MRITM was used to determine the body composition of the mice, and the grip tester was used to measure the grip strength of the mice. The times of drops were measured by the rotary fatigue meter,and the cross-sectional area of gastrocnemius muscle fibers was calculated by HE staining.qRT-PCR was used to analyze MuRF1 and Atrogin-1 gene expressions in the ubiquitin protease pathway.Results After EA treatment,there was no statistically significant difference in body composition between the two groups. Compared with the control group, the mice in the EA treatment group increased their grip strength and cross-sectional area of muscle fibers,but reduced the times of drops and the mRNA expression levels of MuRF1 and Atrogin-1.The difference was statistically significant (P<0.05).Conclusions Ellagic acid may inhibit the degradation of proteins, enhance the muscle function of mice, and improve exercise endurance in mice. It is expected to be a plant compound that improves muscle strength and exercise function.
芦宇婷, 李军, 周仙杰, 吕裕霞, 鲁飞翔, 刘庆春. 鞣花酸提升小鼠肌肉功能的研究及机制探讨[J]. 武警医学, 2020, 31(4): 324-327.
LU Yuting, LI Jun, ZHOU Xianjie, LV Yuxia, LU Feixiang, LIU Qingchun. Effect and mechanism of ellagic acid on muscle function improvement in mice. Med. J. Chin. Peop. Armed Poli. Forc., 2020, 31(4): 324-327.
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2020, Vol. 31 
