Abstract：Objective To investigate the effect of long-term low dose roxithromycin on inflammatory factors in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 98 patients with COPD admitted to our hospital between January 2016 and May 2018 were selected and equally divided into the combined group and the azithromycin group using the random number table method. The azithromycin group was treated with intravenous infusion of azithromycin, once a day and for three months, while the combined group was additionally given six-month treatment with roxithromycin. The time of remission and disappearance of cough, clinical efficacy and the occurrence of complications were recorded. The sputum volume, dyspnea scores, sputum cytokines Ⅱ interferon (gamma-IFN), interleukin 8 (IL-8), tumor necrosis factor (TNF alpha) levels were compared between the two groups before and after treatment. Results Cough relief and disappearance took much less time in the combined group than in the azithromycin group (P<0.05). The total effective rate of the combined group (95.91%) was significantly higher than that of the azithromycin group (75.51%) (P<0.05). Before treatment, there was no significant difference in sputum volumes and dyspnea scores between the two groups. After treatment, the sputum volume and dyspnea scores of the two groups were significantly reduced, especially in the combined group (P<0.05). Before treatment, there was no significant difference between the two groups in levels of γ - IFN, IL-8 and TNF-α. After treatment, these levels in the two groups were decreased, especially in the combined group (P<0.05). After treatment, PEF,FEV1 and FEV1/FVC in the combined group were improved more significantly than in the azithromycin group. Conclusions Long term roxithromycin can reduce airway inflammation, inhibit the levels of inflammatory factors in sputum and improve the lung function of patients with COPD, which is worthy of clinical popularization.
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2020, Vol. 31 
