1. The Second Surgical Department,2. Quality Control Department, Beijing Municipal Corps Hospital, Chinese People’s Armed Police Force, Beijing 100027, China
Abstract：Objective To investigate the effect of sodium hyaluronate combined with celecoxib (CSC) on knee osteoarthritis (KOA) and on expressions of cartilage oligomeric matrix protein (COMP) and osteopontin (OPN).Methods A total of 168 patients with KOA treated in Beijing Municipal Corps Hospital between May 2017 and July 2019 were randomly divided into three groups: celecoxib group (oral administration of celecoxib), sodium hyaluronate group (intra-articular injection of sodium hyaluronate) and CSC group (oral administration of celecoxib and intra-articular injection of sodium hyaluronate), with 56 cases in each group. After four weeks of treatment, the differences in overall efficiency, knee joint function, daily life ability (DLA), serum COM and OPN expressions and adverse reactions were evaluated.Results The total effective rate was significantly different between the three groups (P<0.05). It was significantly higher in the CSC group (94.64%) than in the celecoxib group (82.14%) or in the sodium hyaluronate group (78.57%). After four weeks of treatment, the knee functional scores in each of the three groups were significantly higher, especially in the CSC group (P<0.05). After four weeks of treatment, the DLA scores in the three groups were significantly reduced, especially in the CSC group (P<0.05). The levels of serum COMP and OPN in the three groups were significantly reduced after treatment, particularly in the CSC group (P<0.05). There was no significant difference in the incidence of adverse reactions between the three groups (P>0.05).Conclusions The combination of sodium hyaluronate and celecoxib has better curative effect against KOA, which can improve knee function and daily life ability. Its efficacy may be related to the inhibition of serum COMP and OPN expressions.
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2020, Vol. 31 
