Seshasai S R, Wijesuriya S, Sivakumaran R, et al. Effect of aspirin on vascular and nonvascular outcomes: meta-analysis of randomized controlled trials[J]. Arch Intern Med, 2012, 172(3): 209-216.
Mitrugno A, Sylman J L, Ngo A T, et al.Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation:Implications for the oncoprotein c-MYC[J].Am J Physiol Cell Physiol, 2017, 312(2): C176-C189.
[7]
Gong W H, Zhao N, Zhang Z M, et al. The inhibitory effect of resveratrol on COX-2 expression in human colorectal cancer: a promising therapeutic strategy [J]. Eur Rev Med Pharmacol Sci, 2017, 21(5): 1136.
[8]
杨宝峰.药理学[M]. 8版. 北京:人民卫生出版社, 2013:511-512.
[9]
Muthuswamy R, Okada N J, Jenkins F J, et al. Epinephrine promotes COX-2-dependent immune suppression in myeloid cells and cancer tissues[J].Brain Behav Immun,2017, 62: 78-86.
[10]
Lin H R, Wu Y H, Yen W C, et al. Diminished COX-2/PGE2-mediated antiviral response due to impaired NOX/MAPK signaling in G6PD-knockdown lung epithelial cells [J]. PLoS One, 2016,11(4): e0153462.
Pan P, Huang Y W, Oshima K, et al. Could aspirin and diets high in fiber act synergistically to reduce the risk of colon cancer in humans?[J]. Int J Mol Sci, 2018, 19(1):166.
Stegner D, Dutting S, Nieswandt B. Mechanistic explanation for platelet contribution to cancer metastasis[J]. Thromb Res, 2014, 133 (Suppl. 2):S149-157.
[19]
Peterson J E, Zurakowski D, Italiano J E, et al. Normal ranges of angiogenesis regulatory proteins in human platelets[J]. Am J Hematol, 2010, 85(7): 487-493.
[20]
Bezugla Y, Kolada A, Kamionka S, et al. COX-1 and COX-2 contribute differentially to the LPS-induced release of PGE2 and TxA2 in liver macrophages[J].Prostaglandins Other Lipid Mediat, 2006,79(1-2):93-100.
Lichtenberger L M, Fang D, Bick R J, et al.Unlocking aspirin’s chemopreventive activity:role of irreversibly inhibiting platelet cyclooxygenase-1[J].Cancer Prev Res, 2017,10 (2) :142-152.
Yang C M, Chen Y W, Chi P L, et al. Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-kappaB in human rheumatoid arthritis synovial fibroblasts[J]. Biochem Pharmacol,2017, 132 :77-91.
[25]
Mao H, Chen M, Wang Y, et al.MicroRNA-21 regulates the ERK/NF-kappaB signaling pathway to affect the proliferation migration,and apoptosis of human melanoma A375 cells by targeting SPRY1,PDCD4,and PTEN[J]. Mol Carcinog, 2017, 56(3): 886-894.
[26]
Peng H, Chen Y, Gong P, et al. Higher methylation intensity induced by EBV LMP1 via NF-kappaB/DNMT3b signaling contributes to silencing of PTEN gene[J]. Oncotarget, 2016, 7(26): 40025-40037.
Renault T T, Dejean L M, Manon S. A brewing understanding of the regulation of Bax function by Bcl-xL and Bcl-2[J]. Mech Ageing Dev, 2017,161: 201-210.
Zhu J, Zhou Q, Tan S. Targeting miRNAs associated with surface expression of death receptors to modulate TRAIL resistance in breast cancer[J].Cancer Lett,2016,383(2):154-160.
Din F V, Valanciute A, Houde V P, et al. Aspirin inhibits mTOR signaling,activates AMP-activated protein kinase,and induces autophagy in colorectal cancer cells[J].Gastroenterology, 2012, 142(7): 1504-1515.
[38]
Ledford D K, Lockey R F. Aspirin or nonsteroidal anti-inflammatory drug-exacerbated chronic rhinosinusitis[J].J Allergy Clin Immunol Pract,2016,4(4):590-598.
[39]
Waris G, Ahsan H. Reactive oxygen species: role in the development of cancer and various chronic conditions[J]. J Carcinog, 2006, 5: 14.
[40]
Weinberg F, Chandel N S. Reactive oxygen species-dependent signaling regulates cancer[J].Cell Mol Life Sci, 2009, 66(23): 3663-3673.
[41]
Fiaschi T, Chiarugi P. Oxidative stress,tumor microenvironment,and metabolic reprogramming: a diabolic liaison[J].Int J Cell Biol, 2012, 2012: 762825.
Hagos G K, Carroll RE, Kouznetsova T, et al.Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo[J].Mole Cancer Therapeutics, 2007,6(8) : 2230-2239.
[46]
应 俊. 阿司匹林对结肠癌肝转移的预防作用及其机制研究[D].上海:第二军医大学,2014.
[47]
Van Liesout E M ,Tiemessen D M, Roelofs H M, et al.Nonsteriodal anti-inflammatory drugs enhanced glutathione S-transferase theta levels in rat colon[J] .Biochem Biophys Acta,1998,1318(3):305 -311 .
2020, Vol. 31 
