Abstract：Objective To investigate changes of white matter in patients with vascular depression and its response to drugs, and to provide data for clinical diagnosis and treatment.Methods Depression patients over 65 who were treated at Beijing Longfu Hospital between April 2017 and December 2018 were selected and assessed with the self-rating depression scale (SDS) and Montreal Cognitive Assessment (MoCA). Head MRI was performed. The correlations between SDS scores of the depression scale, MRI high signal scores of white matter and MoCA scores were analyzed. After 12 weeks of treatment with escitalopram , SDS was calculated a second time and the therapeutic effect was observed.Results (1) SDS had a significant positive correlation with MRI lateral ventricle white matter scores, deep white matter scores, and Fazekas scores, respectively. The correlation coefficient r was 0.719, 0.651, and 0.700, respectively, and P values were all 0.000. SDS had a significant negative correlation with MoCA, and the correlation coefficient r was -0.696 and P=0.000. (2) After treatment with escitalopram, SDS scores decreased, and there was statistically significant difference after treatment(t=12.899,P=0.000).Conclusions The white matter high signals displayed by the head MRI are associated with vascular depression and is a risk factor for depression. Escitalopram has a good effect on vascular depression.
王锐, 杨志强, 赵广珍, 许研杰, 吴延华. 血管性抑郁患者脑白质改变及其对药物的反应性[J]. 武警医学, 2021, 32(2): 112-114.
WANG Rui, YANG Zhiqiang, ZHAO Guangzhen, XU Yanjie, WU Yanhua. Changes of white matter in patients with vascular depression and its response to drugs. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(2): 112-114.
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