Abstract：Objective To investigate the effect of N-acetylcysteine on levels of inflammatory factors and pulmonary surfactant protein in bronchoalveolar lavage fluid (BALF) after acute lung injury. Methods One hundred patients with acute lung injury admitted to our hospital between February 2017 and January 2020 were selected and randomly divided into the control group (50 cases) and observation group (50 cases). After admission, both groups were given bronchoalveolar lavage and mechanical ventilation. The control group was given conventional treatment, and the observation group was additionally treated with N-acetylcysteine. The lung function indexes and oxygen saturation of the two groups after treatment were observed. The expressions of TNF-α, IL-1 β and NF kb in BALF were compared between the two groups before and after treatment. The changes of surfactant protein-A (SP-A) and surfactant protein-B (SP-B) were observed before and after treatment. Results After treatment, the blood gas indexes and pulmonary function indexes of the observation group were better than those of the control group (P<0.05), and the levels of TNF - α, IL-1 β and NF kb in BALF of the two groups were decreased, especially in the observation group (P<0.05). After treatment, the levels of SP-A and SP-B in the observation group were significantly higher than those of the control group (P<0.05). Conclusions Acetylcysteine solution for inhalation can reduce the inflammatory response of acute lung injury, improve the patients' lung function, increase the level of lung surfactant protein, and help protect against lung injury. It is clinically worthy of application.
刘苔, 李娅, 杜卫祺, 王力军, 王红飞. 乙酰半胱氨酸溶液对急性肺损伤肺泡灌洗液中炎性因子及肺表面活性蛋白的影响[J]. 武警医学, 2021, 32(6): 464-467.
LIU Tai, LI Ya, DU Weiqi, WANG Lijun, WANG Hongfei. Effects of N-acetylcysteine on levels of inflammatory factors and pulmonary surfactant protein in alveolar lavage fluid of acute lung injury. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(6): 464-467.
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