散结镇痛胶囊联合去氧孕烯炔雌醇片治疗轻型子宫内膜异位症的疗效和安全性

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摘要目的探讨散结镇痛胶囊联合去氧孕烯炔雌醇片治疗轻型子宫内膜异位症(endometriosis,EMT)的疗效和安全性。方法选取2013-12至2017-05在应急总医院和武警北京总队医院妇科就诊的轻型EMT患者90例,均无手术指征,按照随机数字表法分为研究组和对照组,每组45例。研究组于月经第1天开始口服散结镇痛胶囊1.6 g,3次/d,连续服用6个月;同时于月经第1天开始口服去氧孕烯炔雌醇片1片/d,连服21 d,停药第8天开始新的周期,共6个月。对照组给予去氧孕烯炔雌醇片,方法、剂量同研究组。患者治疗前、后行妇科检查、视觉模拟评分法(VAS)评分、妇科超声、心电图、肝肾功能、凝血功能、CA125检查。结果研究组治愈率(73.3%)和总有效率(97.8%)均高于对照组(治愈率31.1%,总有效率82.2%),差异均有统计学意义(P<0.05);治疗后VAS评分研究组[(1.9±1.1)分]明显低于对照组[(2.7±1.8)分],差异有统计学意义(P<0.05);治疗后血清CA125研究组[(19.62±11.13)U/ml]明显低于对照组[(24.78±13.21)U/ml],差异有统计学意义(P<0.05)。结论散结镇痛胶囊联合去氧孕烯炔雌醇片治疗轻型子宫内膜异位症安全有效。

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	祝鑫瑜
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关键词 ：散结镇痛胶囊, 去氧孕烯炔雌醇片, 子宫内膜异位症

Abstract：Objective This research aims to investigate the efficacy and safety of the Sanjie Zhentong capsule combined with desogestrel and ethinylestradiol tablets in the treatment of mild endometriosis.Methods From December 2013 to May 2017, in China Emergency General Hospital and Beijing Municipal Corps Hospital of Chinese People's Armed Police Force, a total of 90 patients with mild endometriosis without surgical indications were randomly allocated into either the Study Group (n=45) or the Control Group (n=45). The study group took Sanjie Zhentong capsules orally from the first day of menstruation, 1.6g each and three times per day. Simultaneously, one desogestrel and ethinylestradiol tablet was taken orally in the evening from the first day of menstruation for 21 days. A new cycle was started on the eighth day of withdrawal.The research lasted for six consecutive months. The control group was given only desogestrel ethinylestradiol tablets, and the method was the same as that of the study group. The patients were examined before and after treatment, including gynecological examination, visual analogue scale (VAS) score, B ultrasound, electrocardiogram, liver and kidney function, coagulation function, and CA125.Results The cure rate of the study group was 73.3%, and that of the control group was 31.1%, the difference was statistically significant (P< 0.05); The total effective rate of the study group was 97.8%, and that of the control group was 82.2%, the difference was statistically significant (P< 0.05); The score of VAS in the study group was (1.9±1.1) and that of in control group was (2.7±1.8) after treatment, the difference was statistically significant (P< 0.05); The value of serum CA125 in the study group was (19.62±11.13)U/ml, and that of in control group was (24.78±13.21)U/ml, the difference was statistically significant (P<0.05).Conclusions Sanjie Zhentong capsule combined with desogestrel and ethinylestradiol tablets is safe and effective in treating mild endometriosis.

Key words： Sanjie Zhentong capsule desogestrel and ethlinylestradiol tablets endometriosis

收稿日期: 2021-04-10

ZTFLH:

R711.71

通讯作者: 张云鹤,E-mail:zcrane181@sina.com

作者简介: 祝鑫瑜,硕士,主治医师。

引用本文:

祝鑫瑜, 毛月芳, 星丽娜, 张云鹤. 散结镇痛胶囊联合去氧孕烯炔雌醇片治疗轻型子宫内膜异位症的疗效和安全性[J]. 武警医学, 2021, 32(9): 773-775. ZHU Xinyu, MAO Yuefang, XING Lina, ZHANG Yunhe. Clinical study on combined Sanjie Zhentong capsule and desogestrel and ethlinylestradiol tablets in treatment of mild endometriosis. Med. J. Chin. Peop. Armed Poli. Forc., 2021, 32(9): 773-775.

链接本文:

http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2021/V32/I9/773

[1]	Sieberg C B,Lunde C E,Borsook D.Endometriosis and pain in the adolescent-striking early to limit suffering:a narrative review[J]. Neurosci Biobehav Rev,2020,108:866-876.
[2]	王丽华, 徐景杰,张嫱. 子宫内膜异位症腹腔镜术后应用促性腺激素释放激素激动药联合去氧孕烯炔雌醇的疗效[J]. 武警医学, 2019, 30(3):189-192.
[3]	中华医学会妇产科学分会子宫内膜异位症协作组. 子宫内膜异位症的诊治指南[J]. 中华妇产科杂志, 2015, 50(3):161-169.
[4]	中国中西医结合学会妇产科专业委员会. 子宫内膜异位症中西医结合诊治指南[J]. 中国中西医结合杂志, 2019, 39(10): 1169-1176.
[5]	中华医学会计划生育学分会. 临床诊疗指南与技术操作规范-计划生育分册(2017修订版)[M]. 北京:人民卫生出版社, 2017:20-26.
[6]	周娟, 惠宁. 散结镇痛胶囊治疗子宫内膜异位症的Meta分析[J]. 中国全科医学, 2010, 13(22): 2524-2528.
[7]	谢幸, 孔北华, 段涛. 妇产科学[M]. 9版. 北京:人民卫生出版社, 2018: 261-267.
[8]	卫爱民, 沈宇飞. 散结镇痛胶囊应用于子宫内膜异位症的系统评价[J]. 中国实用医药, 2014, 9(32):71-72.
[9]	葛雯, 陶倩, 阮洪生, 等. 散结镇痛胶囊化学成分药理作用及临床应用研究进展[J]. 中药药理与临床, 2020, 36(4): 227-232.
[10]	苏真真, 柯志鹏, 张新庄, 等. 散结镇痛胶囊入血成分治疗子宫内膜异位症子宫腺肌症及继发性痛经的作用机制探讨[J]. 中国实验方剂学杂志, 2019, 25(17):165-172.
[11]	邹杰, 关铮, 张唯一, 等. 散结镇痛胶囊和达那唑对大鼠子宫内膜异位症治疗效果的比较[J]. 中国中西医结合杂志, 2012, 32 (8 ) : 1112-1116.
[12]	Zou J, Guan Z, Zhang W Y, et al. Beneficial effects of the Chinese herbal medicine Sanjie Zhentong Capsule on experimental endometriosis in rats[J]. Chin J Nat Med, 2013, 11(6) : 666-672.
[13]	潘媛, 曹亮, 邓奕, 等. 散结镇痛片对子宫内膜异位症模型大鼠妊娠功能和激素水平的影响[J]. 现代药物与临床, 2011, 26(6) : 477-480.
[14]	Zhao Y, Luan X, Wang Y. Letrozole combined with oral contraceptives versus oral contraceptives alone in the treatment of endometriosis-related pain symptoms: a pilot study[J]. Gynecol Endocrinol, 2021, 37 (1):51-55.
[15]	Brown J, Crawford T J, Datta S, et al. Oral contraceptives for pain associated with endometriosis [J]. Cochrane Database Syst Rev, 2018, 5(5): CD001019.