Clinical efficacy of butylphthalide injection combined with acupuncture-moxibustion against acute cerebral infarction
XU Peng1, HOU Shuangxing2
1. The First Department of Geronotology, 960th Hospital of Joint Logistics Support Force, Jinan 250031, China; 2. Department of Neurology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, China
Abstract：Objective To observe the clinical efficacy of butylphthalide injection combined with acupuncture-moxibustion in patients with acute cerebral infarction. Methods Ninety-two patients with acute cerebral infarction were selected and divided into the control group (n=46) and observation group (n=46). The patients in the control group were given intravenous injection of butylphthalide as well as antiplatelet and anticoagulant drugs, while those in the observation group received acupuncture treatment besides the medication mentioned above. The course of treatment was two weeks. The clinical effects were recorded and compared between the two groups. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the neurological function before and after treatment, and the self-care ability of patients was assessed by the Barthel scale. The neurological function index (neuron specific enolase (NSE), vascular endothelial growth factor (VEGF), and S100B protein were measured before and after treatment, so were the hemorheological index and coagulation index (PAC-1, D-Dimer). Adverse reactions were recorded during treatment. Results After treatment, the total effective rate in the observation group was better than in the control group (P＜0.05). The NIHSS scores of the two groups were lower (P＜0.05), especially in the observation group (P＜0.05), but Barthel scores of self-care ability of the two groups were higher (P＜0.05), especially in the observation group (P＜0.05). Hemorheological indexes of the two groups were lower (P＜0.05), especially in the observation group (P＜0.05). Levels of NSE and S100B protein of the two groups were lower (P＜0.05), especially in the observation group (P＜0.05), but levels of VEGF of the two groups were higher (P＜0.05), especially in the observation group (P＜0.05). PAC-1 and D-Dimer of the two groups were lower (P＜0.05), especially in the observation group (P＜0.05). Adverse reactions occurred in the control group (17.50%) and in the observation group (42.86%). Conclusions Butylphthalide combined with acupuncture can improve the neurological function and blood coagulation of patients with acute cerebral infarction, with better clinical efficacy, safety and reliability.
Powers W J, Rabinstein A A, Ackerson T, 等. 2018美国卒中协会/美国心脏协会急性缺血性卒中患者早期管理指南 [J]. 中国脑血管病杂志, 2018, 15(3):162-169.
[5]
Chalos V, van der Ende N A M, Lingsma H F, et al. National institutes of health stroke scale: an alternative primary outcome measure for trials of acute treatment for ischemic stroke[J]. Stroke,2020,51 (1): 282-290.
Liu X, Jin X, Chen B, et al. Effects of kudiezi injection on serum inflammatory biomarkers in patients with acute cerebral infarction[J]. Dis Markers,2018, 2018: 7936736.
[15]
GÖksülük H, Güleç S, Özyüncü N, et al. Comparison of frequency of silent cerebral infarction after coronary angiography and stenting with transradial versus transfemoral approaches[J]. Am J Cardiol, 2018,122 (4): 548-553.
2021, Vol. 32 
