Abstract：Objective To explore the effect of hypothermia treatment on endothelin-1 (ET-1) in patients with severe traumatic brain injuries.Methods Clinical data of 52 patients with severe traumatic brain injuries treated at the department of neurosurgery (cerebral hemorrhage) in Shandong Provincial Corps Hospital of PAP from June 2015 to June 2020 were analyzed retrospectively. The patients were divided into hypothermia treatment group (observation group) and control group with 26 patients in each group. The control group were treated with conventional treatment, and the observation group were treated with hypothermia combined with conventional methods. ET-1 changes, intracranial pressure,Glasgow Outcome Scale(GOS) and ability of daily life(ADL) were compared to assess the efficacy.Results ET-1[(124.6±10.2),(91.7±8.4), (66.2±5.5),(45.4±4.6)ng/L] in the observation group on the 3,5,7 and 14 days after treatment were significantly lower than that in the control group [(130.4±8.7),(99.6±10.6),(72. 8±9.8),(52.0±6.8)ng/L], and the difference was statistically significant(P<0.05). Intra-cranial pressure[(18.0±3.2), (15.5±4.3), (14.5±3.2), (13.0±3.5) mmHg] in the observation group on the 3, 5, 7 and 14 days after treatment was significantly lower than that in the control group[ (19.8±4.0), (18.4±4.6), (17.5±3.7), (16.2±3.7) mmHg ](P<0.05), and the difference was statistically significant(P<0.05). GOS scores of the patients in the observation group (4.12±0.99) were higher than those in the control group (3.54±1.07) after three months, and the difference was statistically significant (t=2.981, P＜0.01). ADL scores of the patients in the observation group (80.19±32.91) were higher than those in the control group (63.85±36.78) after three months, and the difference was statistically significant (t=3.198, P＜0.01).Conclusions Hypothermia treatment can effectively lower the serum level of ET-1 and significantly improve prognosis in the severe traumatic brain injury patients.
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WANG Chunlai, NING Yong, SHANG Jingrui. Effect of hypothermia treatment on endothelin-1 in patients with severe traumatic brain injuries. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(4): 315-318.
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