Objective To evaluate the role of amide proton transfer-weighted (APTw) MRI in differentiating neoplastic and infective mass lesions in children.Methods Thirty-five children with intracranial tumor and 12 children with intracranial infection who were admitted into Beijing Children's Hospital from February 2016 to August 2019 were included in this study. APTw imaging and conventional MR sequences were performed with a MRI scanner. The independent sample t test was used to compare the APTw values of neoplastic and infective mass lesions. One-way analysis of variance and Dunnett T3 post-hoc test was used to compare the APTw values of different intracranial mass lesions (ICMLs) (low-grade intracranial tumors, high- grade intracranial tumors and infective mass lesions). ROC curve analysis was used to evaluate the application value of APTw in the identification of neoplastic and infective mass lesions and the identification of ICMLs.Results The APTw value of infective mass lesions was significantly lower than that of neoplastic mass lesions. The best cut-off value of APTw for distinguishing neoplastic and infective mass lesions was 2.30%, the sensitivity and specificity were 88.6% and 70.8% respectively, and the area under the curve was 0.857.Conclusions APTw MRI imaging can distinguish neoplastic mass lesions from infective mass lesions and different types of ICMLs.
张宏, 吕艳秋, 尹光恒, 王岩, 胡迪, 彭芸. 酰胺质子转移加权成像在鉴别儿童颅内肿瘤性和感染性肿块病变中的应用[J]. 武警医学, 2022, 33(12): 1023-1027.
ZHANG Hong, LYU Yanqiu, YIN Guangheng, WANG Yan, HU Di, PENG Yun. Application value of APTw imaging in differentiation of intracranial neoplastic and infective mass lesions in children. Med. J. Chin. Peop. Armed Poli. Forc., 2022, 33(12): 1023-1027.
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2022, Vol. 33 
