Analysis of influencing factors of orthokeratology on adolescents with myopia
LI Menghan1, ZHANG Jing2, LI Chen2, GAI Shanshan1,2, YU Jia1, YANG Yu3, ZHOU Yuehua1,2
1. Academy of Ophthalmology ,Chengdu University of Traditional Chinese Medicine, Chengdu 610075,China; 2. Beijing Ming Vision and Ophthalmology Hospital, Beijing 100191,China; 3. Department of Ophthalmology,Nanchong Central Hospital,Nanchong 637003,China
Abstract：Objective To explore the influencing factors of orthokeratology on adolescents with myopia. Methods In this retrospective clinical case-control study,408 myopia participants (408 eyes) who wore Orthokeratology lens more than 2 years from December 2015 to November 2021 in Beijing Ming Vision and Ophthalmology were enrolled. The axial length increment of the two groups was compared before and after wearing glasses for 6 M, 1Y and 2 Y. The participants who the increase of ocular axis length after wearing Orthokeratology lens for 2 year is less than or equal to 0.60 mm from the baseline, were divided into experimental group, and the participants who the increase of ocular axis length is more than 0.60 mm from the baseline were divided into a control group. The effects of gender, age, diopter, intraocular pressure, corneal curvature, corneal mean e, corneal astigmatism, basic axial length, central corneal thickness, anterior chamber depth, corneal transverse diameter, pupil diameter, and the relationship between defocus ring and pupil position on axial length growth were analyzed. Results Univariate comparison showed that there were significant differences in pre-treatment age years, pre-treatment diopter,average corneal e, central corneal thickness,basic axial length and relationship between defocus ring and pupil position between the well-controlled group and poor-controlled group (P<0.05). According to multivariate logistic regression analysis, age(OR=1.875), diopter(OR=0.740),and the relationship between defocus ring and pupil position(cross OR=5.887)were independent factors affecting the effect of orthokeratology on myopia control (P<0.05). Conclusions Long-term wearing orthokeratology can control the progression of myopia. Orthokeratology has better control effect on adolescents with myopia who have smaller pre-treatment diopter,the older pre-treatment age and crossed defocusing ring and pupil position.
Holden B A, Fricke T R, Wilson D A, et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050[J]. Ophthalmology, 2016, 123(5): 1036-1042.
[2]
Morgan I G, French A N, Ashby R S, et al. The epidemics of myopia: aetiology and prevention[J].Prog Retin Eye Res,2018, 62: 134-149.
[3]
Ha A, Kim C Y, Shim S R, et al. Degree of myopia and glaucoma risk: adose-response meta-analysis[J]. Am J Ophthalmol, 2022, 236: 107-119.
[4]
Foo L L, Lanca C, Wong C W, et al. Cost of myopia correction: asystematicreview[J]. Front Med, 2021, 8: 718-724.
[5]
Walline J J, Lindsley K B, Vedula S S, et al. Interventions to slow progression of myopia in children[J]. Cochrane Database Syst Rev, 2020,1(1):CD004916.
Na KS, Yoo YS, Hwang H S, et al. The influence of overnight orthokeratology on ocular surface and meibomian glands in children and adolescents[J]. Eye Contact Lens, 2016, 42(1): 68-73.
[9]
Singh K, Bhattacharyya M, Goel A, et al. Orthokeratology in moderate myopia:astudy of predictability and safety[J]. J Ophthal Vis Res, 2020, 15(2): 210-217.
[10]
Guan M, Zhao W, Geng Y, et al. Changes in axial length after orthokeratology lens treatment for myopia: a meta-analysis[J]. Int Ophthalmol, 2020, 40(1): 255-265.
[11]
Hu P, Zhao Y, Chen D, et al. The safety of orthokeratology in myopic children and analysis of related factors[J]. Contact Lens Anterio, 2021, 44(1): 89-93.
Gifford K L, Gifford P, Hendicott P L, et al. Stability of peripheral refraction changes in orthokeratology for myopia[J].Contact Lens Anterio, 2020, 43(1): 44-53.
[14]
González J M, Faria-Ribeiro M A, Lopes D P, et al. Changes in peripheral refractive profile after orthokeratology for different degrees of myopia[J]. Curr Eye Res, 2016, 41(2): 199-207.
[15]
Kang P, Swarbrick H. The influence of different oklensdesigns on peripheral refraction[J]. Optometry Vision Sci, 2016, 93(9): 1112-1119.
[16]
Lin Z, Toledo R, Manzanera S, et al. Two-dimensional peripheral refraction and retinal image quality in orthokeratology lens wearers[J]. Biomed Opt Express, 2020, 11(7): 3523.
Kong Q, Guo J, Zhou J, et al. Factors determining effective orthokeratology treatment for controlling juvenile myopia progression[J]. Iran J Public Health, 2017, 46(9): 6.
[19]
Santodomingo R J, Collar C, Gilmartin B, et al. Factors preventing myopia progression with orthokeratology correction[J]. Optometry Vision Sci, 2013, 90(11): 1225-1236.
2023, Vol. 34 
