Longitudinal analysis of genetic role of skull base morphology in mixed dentition girls
ZHU Changfeng1, PENG Jing2
1. Department of Stomatology, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing 100039, China; 2. Department of Stomatology, the Third Medical Center of Chinese PLA General Hospital, Beijing 100039, China
Abstract：Objective To find the longitudinal genetic effects on cranial base in mixed dentition. Methods Lateral cranial radiographs of 89 pairs of twins were measured. Mixed longitudinal observation method was used to obtain 183 pairs of effective twins, including 110 identical pairs and 73 fraternal pairs. Twin study method was used to conduct the longitudinal statistical analysis of genetic and environmental effects of skull base morphology. Results Statistical comparisons revealed significant (P<0.05) environmental effects on the angle (NSBa), the depths (SN, L1-2, L2+3, L2) ; whilst genetic effects on the depth (SBa) and the height (H2) (P<0.05). Conclusions The variation of skull base structure length is strongly controlled by heredity and weakly influenced by environment. The sphenoccipital complex is the most affected by environment among all the parts of skull base, which has certain clinical significance. NSBa Angle is relatively stable and established earlier.
Fleming P S.Timing orthodontic treatment: early or late [J].Aust Dent J,2017,62(1 Suppl): 11-19.
[2]
Woon S C,Thiruvenkatachari B. Early orthodontic treatment for ClassⅢ malocclusion: a systematic review and meta analysis[J]. Am J Orthod Dentofacial Orthop, 2017,151(1):28-52.
[3]
Maspero C, Galbiati G, Giannini L, et al. Class Ⅱ division 1 malocclusions:comparisons between one-and two-step treatment[J]. Eur J Paediatr Dent, 2018,19(4):295-299.
[4]
Grippaudo M M, Quinzi V, Manai A, et al. Orthodontic treatment need and timing:assessment of evolutive malocclusion conditions and associated risk factors[J]. Eur J Paediatr Dent, 2020,21(3): 203-208.
[5]
Kang G W, Kim Y H, Hong C, et al. Heritability of maxillary dental cephalometric variables among monozygotic twins,dizygotic twins and their siblings[J].Clin Oral Investing, 2022,26(10): 6275-6281.
Shapiro B L. A twin study of palatal dimensions partitioning genetic and environmental contributions to variability[J].Angle Orthod,1969,39(3):139-151.
[15]
赵志河,周彦恒,白玉兴.口腔正畸学[M].7版.北京:人民卫生出版社,2020:11-29.
[16]
Proffit W R.Contemporary orthodontics [M]. 6th ed.St.Louis:Mosby,2018:2-142.
[17]
Moss M L.The functional matrix hypothesis revisited [J]. Am J Orthod Dentofac Orthop, 1997, 112:8-11,221-226,338-342,410-417.
[18]
Lundstr m A. Nature versus nurture in dento-facial variation[J]. Eur J Orthod, 1984, 6(2):77- 91.
[19]
Ishikawa M, Takenaka F,Kikyo T, et al. A morphological study on the maxillofacial growth in Chinese female twins: comparison of the lateral cephalometric resuits with those of Japanese girls [J].Jap J Pedodont,1998,36:613-623.
[20]
Coben S E.The biology of Class II treatment [J]. Am J Orthod, 1971,59:470-487.
[21]
Coben S E.The spheno-occipital synchondrosis:the missing link between the profession's concept of craniofacial growth and orthodontic treatment[J]. Am J Orthod Dentofacial Ortho, 1998,114:709-712.
[22]
Currie K, Sawchuk D, Saltaji H, et al. Posterior cranial base natural growth and development: a systematic review[J].Angle Orthod,2017,87(6):897-910.
[23]
Foley T F, Duncan P G. Soft tissue profile changes in late adolescent males[J]. Angle Orthod, 1997,67(5):373-380.
2023, Vol. 34 
