T-M Takahashi, Sunagawa G A, Soya S, et al. A discrete neuronal circuit induces a hibernation-like state in rodents[J]. Nature, 2020, 583(7814): 109-114.
[3]
S Hrvatin, Sun S, Wilcox O F, et al. Neurons that regulate mouse torpor[J]. Nature, 2020, 583(7814): 115-121.
[4]
V Cogut, Bruintjes J J, Eggen B J L, et al. Brain inflammatory cytokines and microglia morphology changes throughout hibernation phases in Syrian hamster[J]. Brain Behav Immun, 2018, 6817-22.
[5]
A-V Goropashnaya, Toien O, Ramaraj T, et al. Transcriptional changes and preservation of bone mass in hibernating black bears[J]. Sci Rep, 2021, 11(1): 8281.
[6]
B-J Baird, Dickey J S, Nakamura A J, et al. Hypothermia postpones DNA damage repair in irradiated cells and protects against cell killing[J]. Mutat Res, 2011, 711(1-2): 142-149.
[7]
A Drewry, Mohr N M. Temperature Management in the ICU[J]. Crit Care Med, 2022, 50(7): 1138-1147.
[8]
F-S Taccone, Donadello K, Beumier M, et al. When, where and how to initiate hypothermia after adult cardiac arrest[J]. Minerva Anestesiol, 2011, 77(9): 927-933.
[9]
C Zobel, Adler C, Kranz A, et al. Mild therapeutic hypothermia in cardiogenic shock syndrome[J]. Crit Care Med, 2012, 40(6): 1715-1723.
[10]
J-Y Kim, Kim J H, Park J, et al. Targeted temperature management at 36 degrees c shows therapeutic effectiveness via alteration of microglial activation and polarization after ischemic stroke[J]. Transl Stroke Res, 2022, 13(1): 132-141.
[11]
X-N Tang, Yenari M A. Hypothermia as a cytoprotective strategy in ischemic tissue injury[J]. Ageing Res Rev, 2010, 9(1): 61-68.
[12]
S Shankaran, Pappas A, McDonald S A, et al. Childhood outcomes after hypothermia for neonatal encephalopathy[J]. N Engl J Med, 2012, 366(22): 2085-2092.
[13]
M-J Reiniers, Olthof P B, van Golen R F, et al. Hypothermic perfusion with retrograde outflow during right hepatectomy is safe and feasible[J]. Surgery, 2017, 162(1): 48-58.
E Madrid, Urrutia G, Roque I-Figuls-M, et al. Active body surface warming systems for preventing complications caused by inadvertent perioperative hypothermia in adults[J]. Cochrane Database Syst Rev, 2016, 4(4): D9016.
[16]
E-M Moore, Nichol A D, Bernard S A, et al. Therapeutic hypothermia: benefits, mechanisms and potential clinical applications in neurological, cardiac and kidney injury[J]. Injury, 2011, 42(9): 843-854.
[17]
H-B Alam, Duggan M, Li Y, et al. Putting life on hold-for how long? Profound hypothermic cardiopulmonary bypass in a Swine model of complex vascular injuries[J]. J Trauma, 2008, 64(4): 912-922.
[18]
K-W Wang, Ye X L, Huang T, et al. Optogenetics-induced activation of glutamate receptors improves memory function in mice with Alzheimer's disease[J]. Neural Regen Res, 2019, 14(12): 2147-2155.
[19]
K Hristova, Martinez-Gonzalez C, Watson T C, et al. Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation[J]. Brain, 2021, 144(5): 1576-1589.
S Liu, Wang Z, Su Y, et al. A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis[J]. Nature, 2021, 598(7882): 641-645.
[22]
J Cho, Ryu S, Lee S, et al. Clozapine-induced chemogenetic neuromodulation rescues post-stroke deficits after chronic capsular infarct[J]. Transl Stroke Res, 2022.
[23]
N-I Kremer, van Laar T, Lange S F, et al. STN-DBS electrode placement accuracy and motor improvement in Parkinson's disease: systematic review and individual patient meta-analysis[J]. J Neurol Neurosurg Psychiatry, 2022.
[24]
A-R Dawe, Spurrier W A. Hibernation induced in ground squirrels by blood transfusion[J]. Science, 1969, 163(3864): 298-299.
E Blackstone, Morrison M, Roth M B. H2S induces a suspended animation-like state in mice[J]. Science, 2005, 308(5721): 518.
[27]
M Muzzi, Blasi F, Chiarugi A. AMP-dependent hypothermia affords protection from ischemic brain injury[J]. J Cereb Blood Flow Metab, 2013, 33(2): 171-174.
[28]
Q-S Chi, Li X J, Wang D H. 2-Deoxy-D-glucose, not mercaptoacetate, induces a reversible reduction of body temperature in male desert hamsters (Phodopus roborovskii)[J]. J Therm Biol, 2018, 71:189-194.
[29]
K-P Doyle, Suchland K L, Ciesielski T M, et al. Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury[J]. Stroke, 2007, 38(9): 2569-2576.
[30]
C-V Borlongan, Wang Y, Su T P. Delta opioid peptide (D-Ala 2, D-Leu 5) enkephalin: linking hibernation and neuroprotection[J]. Front Biosci, 2004, 93392-3398.
[31]
M-J Paul, Freeman D A, Park J H, et al. Neuropeptide Y induces torpor-like hypothermia in Siberian hamsters[J]. Brain Res, 2005, 1055(1-2): 83-92.
[32]
P Haouzi, Bell H J, Notet V, et al. Comparison of the metabolic and ventilatory response to hypoxia and H2S in unsedated mice and rats[J]. Respir Physiol Neurobiol, 2009, 167(3): 316-322.
[33]
B-S Jensen, Fago A. Sulfide metabolism and the mechanism of torpor[J]. J Exp Biol, 2021, 224(17):236.
[34]
M-C Dirkes, Milstein D M, Heger M, et al. Absence of hydrogen sulfide-induced hypometabolism in pigs: a mechanistic explanation in relation to small nonhibernating mammals[J]. Eur Surg Res, 2015, 54(3-4): 178-191.
[35]
J Dark, Miller D R, Licht P, et al. Glucoprivation counteracts effects of testosterone on daily torpor in Siberian hamsters[J]. Am J Physiol, 1996, 270(2 Pt 2): R398-R403.
[36]
C-C Lee. Is human hibernation possible?[J]. Annu Rev Med, 2008, 59177-186.
[37]
A Puspitasari, Squarcio F, Quartieri M, et al. Synthetic torpor protects rats from exposure to accelerated heavy ions[J]. Sci Rep, 2022, 12(1): 16405.
[38]
A Kamarainen, Virkkunen I, Tenhunen J, et al. Prehospital induction of therapeutic hypothermia during CPR: a pilot study[J]. Resuscitation, 2008, 76(3): 360-363.
[39]
H-N Panas, Lynch L J, Vallender E J, et al. Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout mice[J]. J Neurosci Res, 2010, 88(9): 1962-1969.
[40]
G Chiellini, Frascarelli S, Ghelardoni S, et al. Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function[J]. FASEB J, 2007, 21(7): 1597-1608.
[41]
K Ha, Shin H, Ju H, et al. Behavioral hypothermia of a domesticated lizard under treatment of the hypometabolic agent 3-iodothyronamine[J]. Exp Anim, 2017, 66(2): 99-105.
[42]
H Ju, Shin H, Son C, et al. 3-Iodothyronamine-mediated metabolic suppression increases the phosphorylation of AMPK and induces fuel choice toward lipid mobilization[J]. Horm Metab Res, 2015, 47(8): 605-610.
[43]
P-R Oeltgen, Welborn J R, Nuchols P A, et al. Opioids and hibernation. II. Effects of kappa opioid U69593 on induction of hibernation in summer-active ground squirrels by “hibernation induction trigger” (HIT)[J]. Life Sci, 1987, 41(18): 2115-2120.
[44]
E Soo, Welch A, Marsh C, et al. Molecular strategies used by hibernators: Potential therapeutic directions for ischemia reperfusion injury and preservation of human donor organs[J]. Transplant Rev (Orlando), 2020, 34(1): 100512.
2023, Vol. 34 
