卡瑞利珠单抗注射液临床用药特征分析

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摘要目的探讨卡瑞利珠单抗注射液在真实世界中的用药特征。方法调取解放军第960医院2018-01至2022-04信息管理系统数据库中使用卡瑞利珠单抗治疗患者的数据信息,对患者基本特征进行统计学描述,运用Apriori模型算法对卡瑞利珠单抗联用的药物,以及药理、功能进行分析,以明确卡瑞利珠单抗注射液临床联合用药的情况。结果在306例使用卡瑞利珠单抗的患者中,年龄(64.69±9.62)岁,男女比例为3.31∶1。卡瑞利珠单抗使用例次逐年上升,其中前三位为肺恶性肿瘤(39.93%)、食管恶性肿瘤(28.58%)、胃恶性肿瘤(12.34%)。卡瑞利珠多与抗肿瘤药物+消化系统用药(支持度52.87%)联用,其中消化类药物以止吐催吐药为主。具体药物中,奈达铂+紫杉醇(提升度2.41)、地塞米松+盐酸昂丹司琼(提升度1.73)关联度较高。中成药则以抗恶性肿瘤剂、祛湿剂、补益剂为主。不合理用药84例(242例次,占21.96%),以胃癌、胰腺癌以及肠癌为主。结论作为新型国产抗肿瘤免疫药物,卡瑞利珠单抗越来越受到医师与患者的关注,需要进一步注重其超适应证用药及不良反应采集与处理。

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	孙彦顺
	姜诗瑶
	杨东
	崔钰
	刘青
	于莉莉

关键词 ：卡瑞利珠单抗, 真实世界, 医院信息系统, 联合用药特征

Abstract：Objective To probe the medication characteristics of Camrelizumab injection in the real world. Methods The data information of patients treated with carrilizumab in “HIS” database of the 960th Hospital of Chinese PLA from January 2018 to April 2022 were retrieved, and the basic characteristics of patients were statistically described. The Apriori model algorithm was used to analyze the drugs, pharmacology and function of carrilizumab to clarify the combination of carrilizumab injection in real world. Results Among the 306 patients who used Karelizumab, the average age was (64.69±9.62) years, and the male-female ratio was about 3.31∶1. The use of Karelizumab increased year by year, among which the top three were lung malignant tumor (39.93%), esophageal malignant tumor (28.58%) and gastric malignant tumor (12.34%). Karelizumab was used in combination with anti-tumor drugs and digestive system drugs (the support rate was 52.87%), among which anti-emetic drugs were the main digestive drugs. Among the drugs, nedaplatin+paclitaxel (elevation 2.41) and dexamethasone+ondansetron hydrochloride (elevation 1.73) had high correlation. Chinese patent medicines were mainly anti-malignant tumor agents, dampness-eliminating agents and tonic formulae. Eighty-four cases (242 times, accounting for 21.96%) of irrational drug use were mainly gastric cancer, pancreatic cancer and intestinal cancer. Conclusions As a new domestic anti-tumor immune drug, Karelizumab has attracted more and more attention from physicians and patients, and more attention should be paid to its extra-indication use and collection and treatment of adverse reactions.

Key words： Camrelizumab the real world hospital information system characteristics of combined medication

收稿日期: 2022-09-18

R979.1

基金资助:国家自然科学基金项目(82273729)

通讯作者: 于莉莉, E-mail:yllstat@163.com

作者简介: 孙彦顺, 硕士研究生。

引用本文:

孙彦顺, 姜诗瑶, 杨东, 崔钰, 刘青, 于莉莉. 卡瑞利珠单抗注射液临床用药特征分析[J]. 武警医学, 2023, 34(4): 325-329. SUN Yanshun, JIANG Shiyao, YANG Dong, CUI Yu, LIU Qing, YU Lili. Analysis of medication characteristics of Camrelizumab injection in the real world. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(4): 325-329.

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http://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 http://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2023/V34/I4/325

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