1. Department of Stomatology, Beijing Changping Hospital of Integrated Traditional Chinese and Western Medicine, Beijing 102208, China; 2. Department of Stomatology, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Abstract：Objective To investigate the effects of platelet-rich fibrin (PRF) on periodontal vertical alveolar bone resorption in patients with impaired glucose tolerance.Methods Sixty patients with chronic periodontitis with abnormal glucose tolerance were selected and randomly divided into control (n=30) and PRF (n=30) groups. On the day of periodontal surgery and 6 months after surgery, the serum levels of inflammatory factor interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α), bleeding index (BI), probing depth (PD), attachment loss (AL), bone mean density (BMD) and the height of alveolar in defect zone were determined.Results Six months after periodontal surgery, compared with the control group, IL-6 and TNF-α levels in serum, PD and AL all decreased in the PRF group (P＜0.05).Conclusions PRF intervention can reduce inflammatory factor levels in serum and promote periodontal soft tissue regeneration.
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2023, Vol. 34 
