Expression pattern of TMCO1 in pan-cancer and its correlation with prognosis and immune invasion
DONG Yuan1,2, LI Jialu1,2, WANG Yu3, ZHANG Xiaoli2
1. The Second Clinical Medical College of Southern Medical University, Guangzhou 510515, China; 2. Department of Obstetrics and Gynecology, the Third Medical Center of PLA General Hospital, 100089 Beijing, China; 3. Intelligent Computing Research Institute of Shandong Industrial Technology Research Institute, Jinan 272071, China
Abstract：Objective To investigate the TMCO1 expression levels in pan-cancer and its correlations with prognosis and immune invasion.Methods GEPIA database and TIMER2.0 database were used to analyze the expression levels of TMCO1 in different cancer tissues and adjacent tissues, as well as correlations between TMCO1 expression and the main clinical stages. UCSC database and GEPIA database were used to analyze the prognostic value of TMCO1. Sangerbox database and TIMER2.0 were used to analyze the correlation between TMCO1 and immune cell infiltration and immune checkpoints. Finally, String and GEPIA databases were used to obtain the genes bound or co-expressed with TMCO1 in tumors for GO and KEGG enrichment analysis.Results Compared with normal tissues, the expression of TMCO1 was up-regulated in most tumors and down-regulated in a few tumors. High expression of TMCO1 was associated with poor prognosis of 6 tumors and better prognosis of 1 tumor. TMCO1 was positively correlated with neutrophil infiltration and immune checkpoint gene expression. Enrichment analysis showed that TMCO1 might be related with endoplasmic reticulum stress.Conclusions TMCO1 is a protein associated with the prognosis of various tumors, which is related with neutrophil infiltration, immune checkpoint gene expression and endoplasmic reticulum stress process, and may be a potential tumor therapeutic target in the future.
董媛, 李佳璐, 王宇, 张晓莉. TMCO1在泛癌中的表达模式及其与预后、免疫浸润的相关性分析[J]. 武警医学, 2023, 34(9): 771-780.
DONG Yuan, LI Jialu, WANG Yu, ZHANG Xiaoli. Expression pattern of TMCO1 in pan-cancer and its correlation with prognosis and immune invasion. Med. J. Chin. Peop. Armed Poli. Forc., 2023, 34(9): 771-780.
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2023, Vol. 34 
