老年人握力减弱与静脉血栓栓塞症发病风险的因果关系

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摘要目的探讨老年人握力减弱与静脉血栓栓塞症(VTE)发病风险的因果关系。方法运用孟德尔随机化(MR)方法,分析握力减弱与VTE发病风险之间的因果关联,因果效应主要采用逆方差加权法(IVW)进行评估。计算F统计量检验工具变量的稳定性,运用Cochran’s Q统计法进行异质性检验,并运用加权中位数、MR-Egger回归和留一法评估敏感性和多效性。结果老年人群握力减弱与VTE发病风险之间无因果关联(OR:1.001,95%CI:0.997~1.005,P= 0.524)。进一步分析老年人群握力减弱与深静脉血栓形成(DVT)和肺栓塞(PE)的因果关联后,老年人群握力减弱与DVT(OR:1.002,95%CI:0.999~1.006,P= 0.254)和PE发病风险之间均无因果关联(OR:0.894,95%CI:0.700~1.141,P= 0.368)。结论老年人群的握力减弱与VTE发病风险无因果关联。

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	刘智强
	谭江山
	华潞

关键词 ：老年人, 孟德尔随机化, 握力, 静脉血栓栓塞症

Abstract：Objective To investigate causal association between weakened grip strength and the risk of venous thromboembolism (VTE) in the elderly. Methods The association between weakened grip strength and the risk of VTE was analyzed using Mendelian randomization (MR), and the causal effect was mainly assessed with inverse variance weighting (IVW). The F-statistic was calculated to test the stability of instrumental variables, Cochran's Q-statistic was applied to test for heterogeneity, and sensitivity and pleiotropy were assessed using weighted median, MR-Egger regression and leave-one-out methods. Results There was no causal association between weakened grip strength and the risk of VTE in the elderly (OR: 1.001, 95% CI: 0.997-1.005, P=0.524). In a further analysis of deep vein thrombosis (DVT) and pulmonary embolism (PE), similarly no causal association was found between weakened grip strength and the risk of DVT (OR: 1.002, 95% CI: 0.999-1.006, P=0.254) and PE (OR: 0.894, 95% CI: 0.700-1.141, P=0.368) in the elderly. Conclusions There is no causal association between weakened grip strength and the risk of VTE in the elderly.

Key words： the elderly mendelian randomization grip strength venous thromboembolism

收稿日期: 2024-01-20

ZTFLH:

R543.6

基金资助:中国医学科学院临床与转化医学研究专项(CIFMS)(2022-I2M-C&T-B-040);中国医学科学院阜外医院深圳医院国家心血管疾病临床医学研究中心深圳自主课题(NCRCSZ-2023-015)

通讯作者: 华潞,E-mail: ethannan@126.com

作者简介: 刘智强,硕士,医师。

引用本文:

刘智强, 谭江山, 华潞. 老年人握力减弱与静脉血栓栓塞症发病风险的因果关系[J]. 武警医学, 2024, 35(7): 617-620. LIU Zhiqiang, TAN Jiangshan, HUA Lu. Causal association between weakened grip strength and risk of venous thromboembolism in the elderly. Med. J. Chin. Peop. Armed Poli. Forc., 2024, 35(7): 617-620.

链接本文:

https://journal08.magtechjournal.com/Jwk_wjyx/CN/ 或 https://journal08.magtechjournal.com/Jwk_wjyx/CN/Y2024/V35/I7/617

[1]	Keller K, Hobohm L, Ebner M, et al. Trends in thrombolytic treatment and outcomes of acute pulmonary embolism in Germany [J]. Eur Heart J, 2020, 41(4): 522-529.
[2]	Wendelboe A M, Raskob G E. Global burden of thrombosis: epidemiologic aspects [J]. Circ Res, 2016, 118(9): 1340-1347.
[3]	Kodama S, Saito K, Tanaka S, et al. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis [J]. JAMA, 2009, 301(19): 2024-2035.
[4]	Leong D P, Teo K K, Rangarajan S, et al. Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study [J]. Lancet, 2015, 386(9990): 266-273.
[5]	Wang Y C, Bohannon R W, Li X, et al. Hand-grip strength: normative reference values and equations for individuals 18 to 85 years of age residing in the United States [J]. J Orthop Sports Phys Ther, 2018, 48(9): 685-693.
[6]	Engbers M J, Blom J W, Cushman M, et al. Functional impairment and risk of venous thrombosis in older adults [J]. J Am Geriatr Soc, 2017, 65(9): 2003-2008.
[7]	Leknessundo G R, Morelliv M, Strand B H, et al. Hand grip strength and risk of incident venous thromboembolism: the tromsø study [J]. Res Pract Thr Haemost, 2022, 6(7): e12833.
[8]	Kunutsor S K, Mäkikallio T H, Voutilainen A, et al. Handgrip strength is not associated with risk of venous thromboembolism: a prospective cohort study [J]. Scand Cardiovasc J, 2020, 54(4): 253-275.
[9]	Wang W, Tan J S, Wang J, et al. Genetically predicted waist circumference and risk of atrial fibrillation [J]. Chin Med J (Engl), 2024, 137(1): 82-86.
[10]	Davies N M, Holmes M V, Davey S G. Reading mendelian randomisation studies: a guide, glossary, and checklist for clinicians [J]. BMJ, 2018, 362: k601.
[11]	Elsworth b L M, Alexander T. The MRC IEU OpenGWAS data infrastructure[J]. BMJ, 2020,41:231.
[12]	Jones G, Trajanoska K, Santanasto A J, et al. Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women [J]. Nat Commun, 2021, 12(1): 654.
[13]	Dönertaş H M, Fabian D K, Valenzuela M F, et al. Common genetic associations between age-related diseases [J]. Nat Aging, 2021, 1(4): 400-412.
[14]	Mbatchou J, Barnard L, Backman J, et al. Computationally efficient whole-genome regression for quantitative and binary traits [J]. Nat Genet, 2021, 53(7): 1097-103.
[15]	张露, 郭娜, 郭鸿, 等. 胃食管反流病与慢性阻塞性肺疾病:两样本孟德尔随机化研究 [J]. 中国临床药理学杂志, 2024, 40(3): 440-443.
[16]	杨玉洁, 钟溢源, 郑旭威, 等. 血清代谢物与银屑病的风险一项两样本孟德尔随机化研究 [J]. 中国皮肤性病学杂志, 2024,23: 1-16.
[17]	Hartwig F P, Davey S G, Bowden J. Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption [J]. Int J Epidemiol, 2017, 46(6): 1985-1998.
[18]	刘晓阳, 尹星华, 戴丽, 等. 人工膝关节置换术后下肢深静脉血栓患者的临床特征和高危因素 [J]. 武警医学, 2022, 33(3): 222-225.
[19]	李华, 梁艳, 边晨峰. 食管癌患者静脉血栓栓塞情况及相关因素分析 [J]. 武警医学, 2023, 34(12): 1038-1041.
[20]	罗臻, 郭伟, 王敏. 静脉血栓栓塞相关危险因素的研究进展 [J]. 临床医学进展, 2023, 13(11): 18224-18231.
[21]	Massy N M, Gill T K, Taylor A W, et al. Hand grip strength: age and gender stratified normative data in a population-based study [J]. BMC Res Notes, 2011, 4: 127.
[22]	Lin M H, Chang C Y, Lu C H, et al. Association between grip strength and anthropometric characteristics in the community-dwelling elderly population in Taiwan [J]. PLoS One, 2021, 16(12): e0260763.
[23]	Horvei L D, Brækkan S K, Mathiesen E B, et al. Obesity measures and risk of venous thromboembolism and myocardial infarction [J]. Eur J Epidemiol, 2014, 29(11): 821-830.
[24]	Strandkvist V, Larsson A, Pauelsen M, et al. Hand grip strength is strongly associated with lower limb strength but only weakly with postural control in community-dwelling older adults [J]. Arch Gerontol Geriatr, 2021, 94: 104345.
[25]	Houghton D E, Ashrani A, Liedl D, et al. Reduced calf muscle pump function is a risk factor for venous thromboembolism: a population-based cohort study [J]. Blood, 2021, 137(23): 3284-3290.