Value of CT radiomics in discrimination of hypervascular adrenal adenoma from pheochromocytoma
CHENG Yuanhua1, LU Jing2, HUA Rongrong2, HE Xucheng2, ZHANG Yanan2, WANG Guisheng2, CHEN Xiaoxia2
1. Department of Radiology, Xuanhan People's Hospital of Sichuan Province,636150; 2. Department of Radiology, the Third Medical Center of PLA General Hospital, Beijing 100039, China
Abstract：Objective To explore the value of the CT radiomics model in the differential diagnosis of hypervascular adrenal adenoma (HAA) and pheochromocytoma (AP). Methods A total of 79 patients (53 HAA and 26 AP) who underwent phase 4 CT scan and were pathologically confirmed in the Department of Radiology of the Third Medical Center of PLA General Hospital from January 2022 to July 2024 were retrospectively included. Clinical indicators and radiomics features extracted from CT images through scientific research platform were analyzed. Using the F_Test to reduce dimensionality and screen radiomics features, factors with statistically significant differences were included in binary logistic regression analysis and subsequent modeling. Finally, ROC curve and decision curve of the predictive model were plotted to evaluate its predictive performance and clinical application value. Results The value of plain CT scan (OR=1.166, P<0.01) and the long diameter of tumor (OR=2.226, P<0.01) were independent risk factors for the discrimination of the two groups. The AUC based on CTpre, arterial phase (CTa), late arterial phase (CTla), venous phase (CTv), four-phase combination, imaging features, and clinical indicator model validation set were 0.93, 0.92, 0.88, 0.86, 0.87, 0.88 and 0.72, respectively. The CTpre-based radiomics model was characterized by the best performance, with accuracy, sensitivity, and specificity of 0.86, 0.89, and 0.85, respectively. Conclusions The model based om CT radiomics has good predictive performance and application value in the discrimination of HAA from AP.
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2025, Vol. 36 
