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| Expression of Med-19 proteins in human colon cancer tissue and its signifance |
| DUAN Wei1, DA Chenxing1, GU Yong1, WU Xiuhua1，YANG Yan2，and MENG Hongtao1. |
1. Shaanxi Provincial Corps Hospital of Chinese People’s Armed Police Forces，Xi’an 710054,China;
2. Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an 710032,China |
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Abstract Objective To detect the expression of Med-19 in colon cancer and the correlation between Med-19 expression and pathologic features. Methods The immunohistochemical method was used to detect the expression of Med-19 in 115 colon cancer samples and their corresponding normal tissues. Results The positive rate of Med-19 expression was significantly higher in colon cancer tissues than in the matched normal tissues( P ＜0.05). The positive rate of Med-19 expression was higher in Dukes C+D stage and lymph node metastasis colon cancer tissues than in the matched normal tissues ( P ＜0.05， P ＜0.01). The expression of Med-19 was not related to age, sex, size, or histological differentiation ( P ＞0.05). Conclusions Med-19 is over-expressed in colon cancer tissues，which might be closely related to clinical biological behaviors.
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Received: 01 February 2012
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