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| Molecular mechanism of β-defensin-2 expression in Legionella pneumoniae induced NCI-H292 cells |
| TONG Aihua,MI Yunqiang,LI Kang,and LI Yanyan. |
| Department of Clinical Laboratory,309 Hospital of PLA,Beijing 100091 |
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Abstract Objective To investigate the role of hBD-2 gene for the clinical anti-infective therapy. Methods Legionella pneumoniae infection in NCI-H292 cells, using colony formation assay, Western blotting , and ELISA to investgate the related gene changes in the MAPK pathway. Results hBD-2 inhibited Legionella pneumoniae,and Legionella pneumoniae induced secretion of hBD-2 mainly through the JNK and p38 pathway. Conclusions Legionella pneumoniae induces hBD-2 secreted from NCI-H292 cells,which is mainly due to JNK and p38 pathway.
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Received: 21 January 2012
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. [J]. , 2008, 19(07): 659-661. |
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2012, Vol. 23 
