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| The detection of alpha-fetoprotein isoforms using with centrifugal column method in diagnosis of hepatocelluar carcinoma |
| DI Xiaohui1,ZHENG Fei2,XU Juan1,JIA Zhiling3,and LIU Yang4 |
| 1. Department of Pharmacology, Beijing Military Command General Hospital,BeiJing100700, China; 2. Department of pharmacy,No 302 Hospital of PLA,Beijing 100024,China; 3.Department of oncology laboratory，Beijing Military Command General Hospital,BeiJing100700, China; 4.Department of Pharmacy,the General Hospital of Chinese People’s Armed Police Forces,Beijing100039,China |
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Abstract Objective To explore the clinical significance of alpha-fetoprotein-L3%( AFP-L3) with centrifugal column method in the diagnosis of hepatocelluar carcinoma. Methods The serum samples of 150 patients with elevated AFP level (≥20 ng/ml) were detected by chemiluminescence immunoassay for AFP and centrifugal column method for AFP-L3，and the clinical value of AFP-L3 were studied in the differentiation diagnosis of hepatocelluar cancer. Results Taking AFP-L3≥10 ng/ml as the diagnositic criteria，the sensitivity of AFP-L3 was 91.03% （71/78）in 78 hepatocellular carcinoma patients and the specificity of AFP-L3 was 95.83%(69/72）in 72 other liver diseases patients. The diagnostic accuracy was 93.33%［（71+69）/150］. Conclusion Detection of AFP-L3 seemed be of clinical value in benign or malignant liver disease.
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Received: 11 March 2012
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2012, Vol. 23 
